Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone

•Kynurenine is increased in brain by LPS and plasma by DEX.•Ido1, Ido2 and Tdo2 expression by astrocytes and microglia are uniquely regulated.•DEX attenuates cytokine induction by LPS in peripheral tissues, not brain.•DEX mitigates Ido1 and Ido2 induction by LPS in peripheral tissues, not brain.•Ido...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2018-03, Vol.69, p.321-335
Hauptverfasser:	Dostal, Carlos R., Gamsby, Nicolaus S., Lawson, Marcus A., McCusker, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocyte Brain - drug effects Brain - metabolism Cytokines - metabolism Dexamethasone - pharmacology Glucocorticoids - pharmacology Inflammation Inflammation - metabolism Kynurenine Kynurenine - metabolism Lipopolysaccharides - pharmacology Male Mice Microglia Neuroglia - drug effects Neuroglia - metabolism Signal Transduction - drug effects Stress Stress, Psychological - metabolism
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