Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C

In the management of acute ischemic stroke, vessel recanalization correlates with functional status, mortality, cost, and other outcome measures. Thrombolysis with intravenous tissue plasminogen activator has many limitations that restrict its applicability, but recent advances in the development of...

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Veröffentlicht in:	Neuropharmacology 2018-05, Vol.134 (Pt B), p.293-301
Hauptverfasser:	Amar, Arun Paul, Sagare, Abhay P., Zhao, Zhen, Wang, Yaoming, Nelson, Amy R., Griffin, John H., Zlokovic, Berislav V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated protein C (APC) Animals Endovascular restorative neurosurgery Humans Mechanical neurothrombectomy Neuroprotection Neurorestoration Protein C - metabolism Stroke Stroke - therapy Thrombectomy - methods Thrombolysis Tissue Plasminogen Activator - therapeutic use Treatment Outcome
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