The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus
Purpose of Review This review evaluated gender and race/ethnic representation in randomized controlled trials (RCTs) of patients with systemic lupus erythematosus (SLE). Recent Findings Whites comprise 33% of prevalent SLE cases and comprised 51% of RCT enrollees. Blacks encompass 43% of prevalent S...
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| Veröffentlicht in: | Current rheumatology reports 2018-04, Vol.20 (4), p.20-20, Article 20 |
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| creator | Falasinnu, Titilola Chaichian, Yashaar Bass, Michelle B. Simard, Julia F. |
| description | Purpose of Review
This review evaluated gender and race/ethnic representation in randomized controlled trials (RCTs) of patients with systemic lupus erythematosus (SLE).
Recent Findings
Whites comprise 33% of prevalent SLE cases and comprised 51% of RCT enrollees. Blacks encompass 43% of prevalent SLE cases, but only represented 14% of RCT enrollees. Hispanics comprise 16% of prevalent SLE cases and 21% of RCT enrollees, while Asians comprise 13% of prevalent SLE cases and 10% of RCT enrollees. Males encompass 9% of SLE cases and 7% of RCT enrollees. The reporting and representation of males have remained stable over time, although their representation in RCTs is slighter lower than the prevalence of SLE in males. The representation of Hispanics, Asians, and Native Americans increased over time. However, the representation of blacks among RCT participants has decreased since 2006–2011.
Summary
RCTs among SLE patients need larger sample sizes in order to evaluate heterogeneity in outcomes among racial subgroups. It is imperative that novel strategies be developed to recruit racial minorities with SLE by identifying and improving barriers to RCT enrollment in order to better understand the disease’s diverse population. |
| doi_str_mv | 10.1007/s11926-018-0728-2 |
| format | Article |
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This review evaluated gender and race/ethnic representation in randomized controlled trials (RCTs) of patients with systemic lupus erythematosus (SLE).
Recent Findings
Whites comprise 33% of prevalent SLE cases and comprised 51% of RCT enrollees. Blacks encompass 43% of prevalent SLE cases, but only represented 14% of RCT enrollees. Hispanics comprise 16% of prevalent SLE cases and 21% of RCT enrollees, while Asians comprise 13% of prevalent SLE cases and 10% of RCT enrollees. Males encompass 9% of SLE cases and 7% of RCT enrollees. The reporting and representation of males have remained stable over time, although their representation in RCTs is slighter lower than the prevalence of SLE in males. The representation of Hispanics, Asians, and Native Americans increased over time. However, the representation of blacks among RCT participants has decreased since 2006–2011.
Summary
RCTs among SLE patients need larger sample sizes in order to evaluate heterogeneity in outcomes among racial subgroups. It is imperative that novel strategies be developed to recruit racial minorities with SLE by identifying and improving barriers to RCT enrollment in order to better understand the disease’s diverse population.</description><identifier>ISSN: 1523-3774</identifier><identifier>EISSN: 1534-6307</identifier><identifier>DOI: 10.1007/s11926-018-0728-2</identifier><identifier>PMID: 29550947</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Ethnic Groups ; Female ; Humans ; Lupus Erythematosus, Systemic - drug therapy ; Male ; Medicine ; Medicine & Public Health ; Patient Selection ; Randomized Controlled Trials as Topic ; Rheumatology ; Section Editor ; Sex Factors ; Systemic Lupus Erythematosus (G Tsokos ; Systemic Lupus Erythematosus (G Tsokos, Section Editor) ; Topical Collection on Systemic Lupus Erythematosus</subject><ispartof>Current rheumatology reports, 2018-04, Vol.20 (4), p.20-20, Article 20</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-80aeddd858478a3a74d7aebad4bb7ed702475240cd836c0c9f48b35fb43b3b943</citedby><cites>FETCH-LOGICAL-c442t-80aeddd858478a3a74d7aebad4bb7ed702475240cd836c0c9f48b35fb43b3b943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11926-018-0728-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11926-018-0728-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29550947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Falasinnu, Titilola</creatorcontrib><creatorcontrib>Chaichian, Yashaar</creatorcontrib><creatorcontrib>Bass, Michelle B.</creatorcontrib><creatorcontrib>Simard, Julia F.</creatorcontrib><title>The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus</title><title>Current rheumatology reports</title><addtitle>Curr Rheumatol Rep</addtitle><addtitle>Curr Rheumatol Rep</addtitle><description>Purpose of Review
This review evaluated gender and race/ethnic representation in randomized controlled trials (RCTs) of patients with systemic lupus erythematosus (SLE).
Recent Findings
Whites comprise 33% of prevalent SLE cases and comprised 51% of RCT enrollees. Blacks encompass 43% of prevalent SLE cases, but only represented 14% of RCT enrollees. Hispanics comprise 16% of prevalent SLE cases and 21% of RCT enrollees, while Asians comprise 13% of prevalent SLE cases and 10% of RCT enrollees. Males encompass 9% of SLE cases and 7% of RCT enrollees. The reporting and representation of males have remained stable over time, although their representation in RCTs is slighter lower than the prevalence of SLE in males. The representation of Hispanics, Asians, and Native Americans increased over time. However, the representation of blacks among RCT participants has decreased since 2006–2011.
Summary
RCTs among SLE patients need larger sample sizes in order to evaluate heterogeneity in outcomes among racial subgroups. It is imperative that novel strategies be developed to recruit racial minorities with SLE by identifying and improving barriers to RCT enrollment in order to better understand the disease’s diverse population.</description><subject>Ethnic Groups</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Patient Selection</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Rheumatology</subject><subject>Section Editor</subject><subject>Sex Factors</subject><subject>Systemic Lupus Erythematosus (G Tsokos</subject><subject>Systemic Lupus Erythematosus (G Tsokos, Section Editor)</subject><subject>Topical Collection on Systemic Lupus Erythematosus</subject><issn>1523-3774</issn><issn>1534-6307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UUtv1DAQthAVLQs_gAvykUuoX1k7FyS0WpZKKyG127PlxJPGVWIHO2m1HPnlONpSwaUnj_09xjMfQh8o-UwJkZeJ0oqtC0JVQSRTBXuFLmjJRbHmRL5easYLLqU4R29TuieEEaL4G3TOqrIklZAX6PehA3wNY4QEfjKTCx6HFu_AW4jYeIuvTQOX26nzrsG7GOYxYefzq7dhcL_A4k3vMmZ6fIjO9GmRX3nrHpydl-ujmzp8c0wTDNlhP49zwtt4nDoYzBTSnN6hszYT4f3TuUK337aHzfdi_2N3tfm6Lxoh2FQoYsBaq0olpDLcSGGlgdpYUdcSrCRMyJIJ0ljF1w1pqlaompdtLXjN60rwFfpy8h3negDb5Hmj6fUY3WDiUQfj9P-Id52-Cw-6VKVkkmSDT08GMfycIU16cKmBvjcewpw0I7QUlLC89RWiJ2oTQ0oR2uc2lOglO33KTufs9JKdXjQf__3fs-JvWJnAToSUIX8HUd-HOfq8sxdc_wBmpqg0</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Falasinnu, Titilola</creator><creator>Chaichian, Yashaar</creator><creator>Bass, Michelle B.</creator><creator>Simard, Julia F.</creator><general>Springer US</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus</title><author>Falasinnu, Titilola ; Chaichian, Yashaar ; Bass, Michelle B. ; Simard, Julia F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-80aeddd858478a3a74d7aebad4bb7ed702475240cd836c0c9f48b35fb43b3b943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ethnic Groups</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Patient Selection</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Rheumatology</topic><topic>Section Editor</topic><topic>Sex Factors</topic><topic>Systemic Lupus Erythematosus (G Tsokos</topic><topic>Systemic Lupus Erythematosus (G Tsokos, Section Editor)</topic><topic>Topical Collection on Systemic Lupus Erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Falasinnu, Titilola</creatorcontrib><creatorcontrib>Chaichian, Yashaar</creatorcontrib><creatorcontrib>Bass, Michelle B.</creatorcontrib><creatorcontrib>Simard, Julia F.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current rheumatology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Falasinnu, Titilola</au><au>Chaichian, Yashaar</au><au>Bass, Michelle B.</au><au>Simard, Julia F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus</atitle><jtitle>Current rheumatology reports</jtitle><stitle>Curr Rheumatol Rep</stitle><addtitle>Curr Rheumatol Rep</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>20</volume><issue>4</issue><spage>20</spage><epage>20</epage><pages>20-20</pages><artnum>20</artnum><issn>1523-3774</issn><eissn>1534-6307</eissn><abstract>Purpose of Review
This review evaluated gender and race/ethnic representation in randomized controlled trials (RCTs) of patients with systemic lupus erythematosus (SLE).
Recent Findings
Whites comprise 33% of prevalent SLE cases and comprised 51% of RCT enrollees. Blacks encompass 43% of prevalent SLE cases, but only represented 14% of RCT enrollees. Hispanics comprise 16% of prevalent SLE cases and 21% of RCT enrollees, while Asians comprise 13% of prevalent SLE cases and 10% of RCT enrollees. Males encompass 9% of SLE cases and 7% of RCT enrollees. The reporting and representation of males have remained stable over time, although their representation in RCTs is slighter lower than the prevalence of SLE in males. The representation of Hispanics, Asians, and Native Americans increased over time. However, the representation of blacks among RCT participants has decreased since 2006–2011.
Summary
RCTs among SLE patients need larger sample sizes in order to evaluate heterogeneity in outcomes among racial subgroups. It is imperative that novel strategies be developed to recruit racial minorities with SLE by identifying and improving barriers to RCT enrollment in order to better understand the disease’s diverse population.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29550947</pmid><doi>10.1007/s11926-018-0728-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Current rheumatology reports, 2018-04, Vol.20 (4), p.20-20, Article 20 |
| issn | 1523-3774 1534-6307 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Ethnic Groups Female Humans Lupus Erythematosus, Systemic - drug therapy Male Medicine Medicine & Public Health Patient Selection Randomized Controlled Trials as Topic Rheumatology Section Editor Sex Factors Systemic Lupus Erythematosus (G Tsokos Systemic Lupus Erythematosus (G Tsokos, Section Editor) Topical Collection on Systemic Lupus Erythematosus |
| title | The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus |
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