Cytosolic Delivery of Proteins by Bioreversible Esterification

Cloaking its carboxyl groups with a hydrophobic moiety is shown to enable a protein to enter the cytosol of a mammalian cell. Diazo compounds derived from (p-methylphenyl)­glycine were screened for the ability to esterify the green fluorescent protein (GFP) in an aqueous environment. Esterification...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-10, Vol.139 (41), p.14396-14398
Hauptverfasser:	Mix, Kalie A, Lomax, Jo E, Raines, Ronald T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cricetulus Cytosol - metabolism Esterases - metabolism Esterification Esters - chemistry Esters - metabolism Green Fluorescent Proteins - chemistry Green Fluorescent Proteins - metabolism Prodrugs - chemistry Prodrugs - metabolism
Online-Zugang:	Volltext
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