Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects
Glycation is associated with several neurodegenerative disorders, including Alzheimer's disease (AD), where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ). Published studies support the anti-glycation and neuroprotective effects of several polyphenol-rich fruits,...
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| Veröffentlicht in: | International journal of molecular sciences 2018-02, Vol.19 (2), p.461 |
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| creator | Ma, Hang Johnson, Shelby L Liu, Weixi DaSilva, Nicholas A Meschwitz, Susan Dain, Joel A Seeram, Navindra P |
| description | Glycation is associated with several neurodegenerative disorders, including Alzheimer's disease (AD), where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ). Published studies support the anti-glycation and neuroprotective effects of several polyphenol-rich fruits, including berries, which are rich in anthocyanins. Herein, blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts were evaluated for: (1) total phenolic and anthocyanins contents, (2) free radical (DPPH) scavenging and reactive carbonyl species (methylglyoxal; MGO) trapping, (3) anti-glycation (using BSA-fructose and BSA-MGO models), (4) anti-Aβ aggregation (using thermal- and MGO-induced fibrillation models), and, (5) murine microglia (BV-2) neuroprotective properties. Berry crude extracts (CE) were fractionated to yield anthocyanins-free (ACF) and anthocyanins-enriched (ACE) extracts. The berry ACEs (at 100 μg/mL) showed superior free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects compared to their respective ACFs. The berry ACEs (at 100 μg/mL) inhibited both thermal- and MGO-induced Aβ fibrillation. In addition, the berry ACEs (at 20 μg/mL) reduced H₂O₂-induced reactive oxygen species production, and lipopolysaccharide-induced nitric oxide species in BV-2 microglia as well as decreased H₂O₂-induced cytotoxicity and caspase-3/7 activity in BV-2 microglia. The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD. |
| doi_str_mv | 10.3390/ijms19020461 |
| format | Article |
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Published studies support the anti-glycation and neuroprotective effects of several polyphenol-rich fruits, including berries, which are rich in anthocyanins. Herein, blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts were evaluated for: (1) total phenolic and anthocyanins contents, (2) free radical (DPPH) scavenging and reactive carbonyl species (methylglyoxal; MGO) trapping, (3) anti-glycation (using BSA-fructose and BSA-MGO models), (4) anti-Aβ aggregation (using thermal- and MGO-induced fibrillation models), and, (5) murine microglia (BV-2) neuroprotective properties. Berry crude extracts (CE) were fractionated to yield anthocyanins-free (ACF) and anthocyanins-enriched (ACE) extracts. The berry ACEs (at 100 μg/mL) showed superior free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects compared to their respective ACFs. The berry ACEs (at 100 μg/mL) inhibited both thermal- and MGO-induced Aβ fibrillation. In addition, the berry ACEs (at 20 μg/mL) reduced H₂O₂-induced reactive oxygen species production, and lipopolysaccharide-induced nitric oxide species in BV-2 microglia as well as decreased H₂O₂-induced cytotoxicity and caspase-3/7 activity in BV-2 microglia. The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms19020461</identifier><identifier>PMID: 29401686</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alzheimer's disease ; Animal models ; Anthocyanins ; Berries ; Biocompatibility ; Blueberries ; Carbonyls ; Caspase ; Caspase-3 ; Cytotoxicity ; Fibrillation ; Free radicals ; Fructose ; Fruits ; Glycosylation ; Hydrogen peroxide ; In vivo methods and tests ; Lipopolysaccharides ; Microglia ; Neurodegeneration ; Neuroprotection ; Nitric oxide ; Phenolic compounds ; Polyphenols ; Proteins ; Pyruvaldehyde ; Reactive oxygen species ; Scavenging ; Trapping ; β-Amyloid</subject><ispartof>International journal of molecular sciences, 2018-02, Vol.19 (2), p.461</ispartof><rights>Copyright MDPI AG 2018</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3271-c7421ea62d9e43a79be648cd3dfe0905ca39f3dfa471a85fc0cd99ba2bd89c333</citedby><cites>FETCH-LOGICAL-c3271-c7421ea62d9e43a79be648cd3dfe0905ca39f3dfa471a85fc0cd99ba2bd89c333</cites><orcidid>0000-0001-7565-6889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855683/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855683/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29401686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Hang</creatorcontrib><creatorcontrib>Johnson, Shelby L</creatorcontrib><creatorcontrib>Liu, Weixi</creatorcontrib><creatorcontrib>DaSilva, Nicholas A</creatorcontrib><creatorcontrib>Meschwitz, Susan</creatorcontrib><creatorcontrib>Dain, Joel A</creatorcontrib><creatorcontrib>Seeram, Navindra P</creatorcontrib><title>Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Glycation is associated with several neurodegenerative disorders, including Alzheimer's disease (AD), where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ). Published studies support the anti-glycation and neuroprotective effects of several polyphenol-rich fruits, including berries, which are rich in anthocyanins. Herein, blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts were evaluated for: (1) total phenolic and anthocyanins contents, (2) free radical (DPPH) scavenging and reactive carbonyl species (methylglyoxal; MGO) trapping, (3) anti-glycation (using BSA-fructose and BSA-MGO models), (4) anti-Aβ aggregation (using thermal- and MGO-induced fibrillation models), and, (5) murine microglia (BV-2) neuroprotective properties. Berry crude extracts (CE) were fractionated to yield anthocyanins-free (ACF) and anthocyanins-enriched (ACE) extracts. The berry ACEs (at 100 μg/mL) showed superior free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects compared to their respective ACFs. The berry ACEs (at 100 μg/mL) inhibited both thermal- and MGO-induced Aβ fibrillation. In addition, the berry ACEs (at 20 μg/mL) reduced H₂O₂-induced reactive oxygen species production, and lipopolysaccharide-induced nitric oxide species in BV-2 microglia as well as decreased H₂O₂-induced cytotoxicity and caspase-3/7 activity in BV-2 microglia. The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD.</description><subject>Alzheimer's disease</subject><subject>Animal models</subject><subject>Anthocyanins</subject><subject>Berries</subject><subject>Biocompatibility</subject><subject>Blueberries</subject><subject>Carbonyls</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cytotoxicity</subject><subject>Fibrillation</subject><subject>Free radicals</subject><subject>Fructose</subject><subject>Fruits</subject><subject>Glycosylation</subject><subject>Hydrogen peroxide</subject><subject>In vivo methods and tests</subject><subject>Lipopolysaccharides</subject><subject>Microglia</subject><subject>Neurodegeneration</subject><subject>Neuroprotection</subject><subject>Nitric oxide</subject><subject>Phenolic compounds</subject><subject>Polyphenols</subject><subject>Proteins</subject><subject>Pyruvaldehyde</subject><subject>Reactive oxygen species</subject><subject>Scavenging</subject><subject>Trapping</subject><subject>β-Amyloid</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkk1v1DAQhgMC0VK4cQZLXDg04I98-YK0rLYFqXyoLefIcSZZL1472Mm2-Vv8EH4T3t2wWjj5Hc_jd2asiaIXBL9ljON3arX2hGOKk4w8jE5JQmmMcZY_OtIn0VPvVxhTRlP-JDqhPMEkK7LTB68WG6EH0StrkG3QN6vHbgnGajQz_dLKURhl4oVxSi6hRov73gnZ-y37QQv5owLnxvO9RtfCd4eLASY5d8JM8jpYHEHC1OgmGN7tYtRYhy4cQEBqJYVGN1JswLTKtNunoa7aAJoLV1kzhmwHUoFHt0503Y4JLav4Uo9yN88U__4Vz9ajtqpGs7Z10E7JbfHPSjrbahVqfYHB2c7ZHvZlFk0TlH8WPW6E9vB8Os-i7xeL2_nH-Orr5af57CqWjOYklnlCCYiM1hwSJnJeQZYUsmZ1A5jjVArGmxCIJCeiSBuJZc15JWhVF1wyxs6i93vfbqjWUEsw4V902Tm1Fm4srVDlvxmjlmVrN2VapGlWbA3eTAbO_hzA9-VaeQlaCwN28CXhPCVZjhkN6Ov_0JUdnAnjlRSTpMA0Y0mgzvdU-CLvHTSHZggut5tXHm9ewF8eD3CA_64a-wNtmtwg</recordid><startdate>20180203</startdate><enddate>20180203</enddate><creator>Ma, Hang</creator><creator>Johnson, Shelby L</creator><creator>Liu, Weixi</creator><creator>DaSilva, Nicholas A</creator><creator>Meschwitz, Susan</creator><creator>Dain, Joel A</creator><creator>Seeram, Navindra P</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7565-6889</orcidid></search><sort><creationdate>20180203</creationdate><title>Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects</title><author>Ma, Hang ; Johnson, Shelby L ; Liu, Weixi ; DaSilva, Nicholas A ; Meschwitz, Susan ; Dain, Joel A ; Seeram, Navindra P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3271-c7421ea62d9e43a79be648cd3dfe0905ca39f3dfa471a85fc0cd99ba2bd89c333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alzheimer's disease</topic><topic>Animal models</topic><topic>Anthocyanins</topic><topic>Berries</topic><topic>Biocompatibility</topic><topic>Blueberries</topic><topic>Carbonyls</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cytotoxicity</topic><topic>Fibrillation</topic><topic>Free radicals</topic><topic>Fructose</topic><topic>Fruits</topic><topic>Glycosylation</topic><topic>Hydrogen peroxide</topic><topic>In vivo methods and tests</topic><topic>Lipopolysaccharides</topic><topic>Microglia</topic><topic>Neurodegeneration</topic><topic>Neuroprotection</topic><topic>Nitric oxide</topic><topic>Phenolic compounds</topic><topic>Polyphenols</topic><topic>Proteins</topic><topic>Pyruvaldehyde</topic><topic>Reactive oxygen species</topic><topic>Scavenging</topic><topic>Trapping</topic><topic>β-Amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Hang</creatorcontrib><creatorcontrib>Johnson, Shelby L</creatorcontrib><creatorcontrib>Liu, Weixi</creatorcontrib><creatorcontrib>DaSilva, Nicholas A</creatorcontrib><creatorcontrib>Meschwitz, Susan</creatorcontrib><creatorcontrib>Dain, Joel A</creatorcontrib><creatorcontrib>Seeram, Navindra P</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Hang</au><au>Johnson, Shelby L</au><au>Liu, Weixi</au><au>DaSilva, Nicholas A</au><au>Meschwitz, Susan</au><au>Dain, Joel A</au><au>Seeram, Navindra P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2018-02-03</date><risdate>2018</risdate><volume>19</volume><issue>2</issue><spage>461</spage><pages>461-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Glycation is associated with several neurodegenerative disorders, including Alzheimer's disease (AD), where it potentiates the aggregation and toxicity of proteins such as β-amyloid (Aβ). Published studies support the anti-glycation and neuroprotective effects of several polyphenol-rich fruits, including berries, which are rich in anthocyanins. Herein, blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts were evaluated for: (1) total phenolic and anthocyanins contents, (2) free radical (DPPH) scavenging and reactive carbonyl species (methylglyoxal; MGO) trapping, (3) anti-glycation (using BSA-fructose and BSA-MGO models), (4) anti-Aβ aggregation (using thermal- and MGO-induced fibrillation models), and, (5) murine microglia (BV-2) neuroprotective properties. Berry crude extracts (CE) were fractionated to yield anthocyanins-free (ACF) and anthocyanins-enriched (ACE) extracts. The berry ACEs (at 100 μg/mL) showed superior free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects compared to their respective ACFs. The berry ACEs (at 100 μg/mL) inhibited both thermal- and MGO-induced Aβ fibrillation. In addition, the berry ACEs (at 20 μg/mL) reduced H₂O₂-induced reactive oxygen species production, and lipopolysaccharide-induced nitric oxide species in BV-2 microglia as well as decreased H₂O₂-induced cytotoxicity and caspase-3/7 activity in BV-2 microglia. The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29401686</pmid><doi>10.3390/ijms19020461</doi><orcidid>https://orcid.org/0000-0001-7565-6889</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2018-02, Vol.19 (2), p.461 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Alzheimer's disease Animal models Anthocyanins Berries Biocompatibility Blueberries Carbonyls Caspase Caspase-3 Cytotoxicity Fibrillation Free radicals Fructose Fruits Glycosylation Hydrogen peroxide In vivo methods and tests Lipopolysaccharides Microglia Neurodegeneration Neuroprotection Nitric oxide Phenolic compounds Polyphenols Proteins Pyruvaldehyde Reactive oxygen species Scavenging Trapping β-Amyloid |
| title | Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects |
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