Electrospinning of Chitosan-Based Solutions for Tissue Engineering and Regenerative Medicine
Electrospinning has been used for decades to generate nano-fibres via an electrically charged jet of polymer solution. This process is established on a spinning technique, using electrostatic forces to produce fine fibres from polymer solutions. Amongst, the electrospinning of available biopolymers...
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| Veröffentlicht in: | International journal of molecular sciences 2018-01, Vol.19 (2), p.407 |
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| creator | Qasim, Saad B Zafar, Muhammad S Najeeb, Shariq Khurshid, Zohaib Shah, Altaf H Husain, Shehriar Rehman, Ihtesham Ur |
| description | Electrospinning has been used for decades to generate nano-fibres via an electrically charged jet of polymer solution. This process is established on a spinning technique, using electrostatic forces to produce fine fibres from polymer solutions. Amongst, the electrospinning of available biopolymers (silk, cellulose, collagen, gelatine and hyaluronic acid), chitosan (CH) has shown a favourable outcome for tissue regeneration applications. The aim of the current review is to assess the current literature about electrospinning chitosan and its composite formulations for creating fibres in combination with other natural polymers to be employed in tissue engineering. In addition, various polymers blended with chitosan for electrospinning have been discussed in terms of their potential biomedical applications. The review shows that evidence exists in support of the favourable properties and biocompatibility of chitosan electrospun composite biomaterials for a range of applications. However, further research and in vivo studies are required to translate these materials from the laboratory to clinical applications. |
| doi_str_mv | 10.3390/ijms19020407 |
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This process is established on a spinning technique, using electrostatic forces to produce fine fibres from polymer solutions. Amongst, the electrospinning of available biopolymers (silk, cellulose, collagen, gelatine and hyaluronic acid), chitosan (CH) has shown a favourable outcome for tissue regeneration applications. The aim of the current review is to assess the current literature about electrospinning chitosan and its composite formulations for creating fibres in combination with other natural polymers to be employed in tissue engineering. In addition, various polymers blended with chitosan for electrospinning have been discussed in terms of their potential biomedical applications. The review shows that evidence exists in support of the favourable properties and biocompatibility of chitosan electrospun composite biomaterials for a range of applications. However, further research and in vivo studies are required to translate these materials from the laboratory to clinical applications.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms19020407</identifier><identifier>PMID: 29385727</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Addition polymerization ; Animals ; Biocompatibility ; Biomaterials ; Biomedical materials ; Biopolymers ; Cellulose ; Charging ; Chitosan ; Chitosan - chemistry ; Collagen ; Electrospinning ; Electrostatic properties ; Fibers ; Formulations ; Humans ; Hyaluronic acid ; In vivo methods and tests ; Nanofibers ; Nanoparticles ; Natural polymers ; Polymers ; Regeneration ; Regeneration (physiology) ; Regenerative medicine ; Regenerative Medicine - methods ; Review ; Silk ; Therapeutic applications ; Tissue engineering ; Tissue Engineering - methods</subject><ispartof>International journal of molecular sciences, 2018-01, Vol.19 (2), p.407</ispartof><rights>Copyright MDPI AG 2018</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-9c0656cf6cecafddb62ecb2f58584d433846648ab9e7d8a74137e25deecc31c3</citedby><cites>FETCH-LOGICAL-c412t-9c0656cf6cecafddb62ecb2f58584d433846648ab9e7d8a74137e25deecc31c3</cites><orcidid>0000-0002-3803-6055 ; 0000-0001-7998-7335 ; 0000-0002-7430-7860 ; 0000-0002-5157-7067 ; 0000-0003-2353-3929</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855629/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855629/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29385727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qasim, Saad B</creatorcontrib><creatorcontrib>Zafar, Muhammad S</creatorcontrib><creatorcontrib>Najeeb, Shariq</creatorcontrib><creatorcontrib>Khurshid, Zohaib</creatorcontrib><creatorcontrib>Shah, Altaf H</creatorcontrib><creatorcontrib>Husain, Shehriar</creatorcontrib><creatorcontrib>Rehman, Ihtesham Ur</creatorcontrib><title>Electrospinning of Chitosan-Based Solutions for Tissue Engineering and Regenerative Medicine</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Electrospinning has been used for decades to generate nano-fibres via an electrically charged jet of polymer solution. This process is established on a spinning technique, using electrostatic forces to produce fine fibres from polymer solutions. Amongst, the electrospinning of available biopolymers (silk, cellulose, collagen, gelatine and hyaluronic acid), chitosan (CH) has shown a favourable outcome for tissue regeneration applications. The aim of the current review is to assess the current literature about electrospinning chitosan and its composite formulations for creating fibres in combination with other natural polymers to be employed in tissue engineering. In addition, various polymers blended with chitosan for electrospinning have been discussed in terms of their potential biomedical applications. The review shows that evidence exists in support of the favourable properties and biocompatibility of chitosan electrospun composite biomaterials for a range of applications. However, further research and in vivo studies are required to translate these materials from the laboratory to clinical applications.</description><subject>Addition polymerization</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Biopolymers</subject><subject>Cellulose</subject><subject>Charging</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Collagen</subject><subject>Electrospinning</subject><subject>Electrostatic properties</subject><subject>Fibers</subject><subject>Formulations</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>In vivo methods and tests</subject><subject>Nanofibers</subject><subject>Nanoparticles</subject><subject>Natural polymers</subject><subject>Polymers</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Regenerative medicine</subject><subject>Regenerative Medicine - methods</subject><subject>Review</subject><subject>Silk</subject><subject>Therapeutic applications</subject><subject>Tissue engineering</subject><subject>Tissue Engineering - methods</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctrGzEQxkVoyMPJLeew0EsP2UavlVaXQGuctJAQSH0sCFmadWTWkiPtGvrfRyEPnJ5mYH4z8818CJ0R_J0xhS_9ap2JwhRzLPfQEeGU1hgL-WUnP0THOa8wpow26gAdUsXaRlJ5hP7OerBDinnjQ_BhWcWumj76IWYT6p8mg6v-xH4cfAy56mKq5j7nEapZWPoAkF5aTHDVAywhQDKD30J1B87bUj5B-53pM5y-xQmaX8_m01_17f3N7-mP29pyQodaWSwaYTthwZrOuYWgYBe0a9qm5Y4z1nIheGsWCqRrjeSESaCNA7CWEcsm6Op17GZcrMFZCEMyvd4kvzbpn47G68-V4B_1Mm51WdCI8osJ-vY2IMWnEfKg1z5b6HsTII5ZE6WKCEm5KOjX_9BVHFMo12mKCZdKiZYX6uKVsuWzOUH3IYZg_eKa3nWt4Oe7B3zA7zaxZyoUlW8</recordid><startdate>20180130</startdate><enddate>20180130</enddate><creator>Qasim, Saad B</creator><creator>Zafar, Muhammad S</creator><creator>Najeeb, Shariq</creator><creator>Khurshid, Zohaib</creator><creator>Shah, Altaf H</creator><creator>Husain, Shehriar</creator><creator>Rehman, Ihtesham Ur</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3803-6055</orcidid><orcidid>https://orcid.org/0000-0001-7998-7335</orcidid><orcidid>https://orcid.org/0000-0002-7430-7860</orcidid><orcidid>https://orcid.org/0000-0002-5157-7067</orcidid><orcidid>https://orcid.org/0000-0003-2353-3929</orcidid></search><sort><creationdate>20180130</creationdate><title>Electrospinning of Chitosan-Based Solutions for Tissue Engineering and Regenerative Medicine</title><author>Qasim, Saad B ; 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| subjects | Addition polymerization Animals Biocompatibility Biomaterials Biomedical materials Biopolymers Cellulose Charging Chitosan Chitosan - chemistry Collagen Electrospinning Electrostatic properties Fibers Formulations Humans Hyaluronic acid In vivo methods and tests Nanofibers Nanoparticles Natural polymers Polymers Regeneration Regeneration (physiology) Regenerative medicine Regenerative Medicine - methods Review Silk Therapeutic applications Tissue engineering Tissue Engineering - methods |
| title | Electrospinning of Chitosan-Based Solutions for Tissue Engineering and Regenerative Medicine |
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