Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression

The gene for the glucocorticoid receptor regulator FK506 binding protein 5 (FKBP5) plays a role for risk, response to treatment, and changes in brain areas in major depressive disorder (MDD). Chronic stress is associated with lower methylation of FKBP5. Our aim was to investigate whether methylation...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2018-04, Vol.43 (5), p.1138-1145
Hauptverfasser:	Tozzi, Leonardo, Farrell, Chloe, Booij, Linda, Doolin, Kelly, Nemoda, Zsofia, Szyf, Moshe, Pomares, Florence B, Chiarella, Julian, O'Keane, Veronica, Frodl, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Brain Chi-square test Children Demethylation DNA methylation Emotions Environmental risk Epigenetics Genetic testing Glucocorticoids Hypotheses Magnetic resonance imaging Mental depression Methylation Neuroimaging Neurosciences Original Proteins Psychiatry Regulation Risk factors Stress Structure-function relationships Substantia grisea Tacrolimus Tacrolimus-binding protein Trauma
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!