Pituitary Adenylate Cyclase-Activating Peptide in the Bed Nucleus of the Stria Terminalis Mediates Stress-Induced Reinstatement of Cocaine Seeking in Rats

Stressors often contribute to difficulties in maintaining behavior change following a period of abstinence, and may play a significant role in drug relapse. The activation of pituitary adenylate cyclase-activating peptide (PACAP) systems in the bed nucleus of the stria terminalis (BNST) mediates man...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2018-04, Vol.43 (5), p.978-986
Hauptverfasser:	Miles, Olivia W, Thrailkill, Eric A, Linden, Anne K, May, Victor, Bouton, Mark E, Hammack, Sayamwong E
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Behavior, Addictive Cocaine Cocaine - pharmacology Drug self-administration Drug-Seeking Behavior - drug effects Electric Stimulation Experiments Exposure Extinction Extinction behavior Extinction, Psychological - drug effects Footshock Male Microinjections Nuclei Original PAC1 protein Peptide Fragments - pharmacology Pituitary adenylate cyclase-activating polypeptide Pituitary Adenylate Cyclase-Activating Polypeptide - agonists Pituitary Adenylate Cyclase-Activating Polypeptide - antagonists & inhibitors Pituitary Adenylate Cyclase-Activating Polypeptide - biosynthesis Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology Rats Receptor mechanisms Recurrence Reinstatement Rodents Self Administration Septal Nuclei - metabolism Stress Stress, Psychological - metabolism Stria terminalis Transcription
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