Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

We developed 2 novel lipid nanoparticle-encapsulated, nonreplicating RNA-based Ebola virus vaccines encoding glycoprotein with 1-methylpseudoUTP nucleoside modifications and different signal peptides. Vaccination of guinea pigs elicited high Ebola-specific IgG and neutralizing antibodies and conferr...

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Veröffentlicht in:	The Journal of infectious diseases 2018-01, Vol.217 (3), p.451-455
Hauptverfasser:	Meyer, Michelle, Huang, Eric, Yuzhakov, Olga, Ramanathan, Palaniappan, Ciaramella, Giuseppe, Bukreyev, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Disease Models, Animal Drug Carriers - administration & dosage Ebola Vaccines - administration & dosage Ebola Vaccines - immunology Female Guinea Pigs Hemorrhagic Fever, Ebola - prevention & control Immunoglobulin G - blood Liposomes - administration & dosage Major and Brief Reports RNA, Messenger - administration & dosage RNA, Viral - administration & dosage Survival Analysis
Online-Zugang:	Volltext
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