Evaluation of "IFITM3" rs12252 Association With Severe Pediatric Influenza Infection

Background. Interferon-induced transmembrane protein 3 (IFITM3) restricts endocytic fusion of influenza virus. IFITM3 rs12252_C, a putative alternate splice site, has been associated with influenza severity in adults. IFITM3 has not been evaluated in pediatric influenza. Methods. The Pediatric Influ...

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Veröffentlicht in:	The Journal of infectious diseases 2017-07, Vol.216 (1), p.14-21
Hauptverfasser:	Randolph, Adrienne G., Yip, Wai-Ki, Allen, Emma Kaitlynn, Rosenberger, Carrie M., Agan, Anna A., Ash, Stephanie A., Zhang, Yu, Bhangale, Tushar R., Finkelstein, David, Cvijanovich, Natalie Z., Mourani, Peter M., Hall, Mark W., Su, Helen C., Thomas, Paul G.
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans - genetics Child Child, Preschool Female Genetic Predisposition to Disease Genotyping Techniques Homozygote Humans Influenza A virus Influenza, Human - genetics Major Male Membrane Proteins - genetics PATHOGENESIS AND HOST RESPONSE Polymorphism, Single Nucleotide Prospective Studies Protein Isoforms - genetics RNA, Viral - isolation & purification RNA-Binding Proteins - genetics
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