Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model
Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and dep...
Gespeichert in:
| Veröffentlicht in: | International journal of psychophysiology 2018-09, Vol.131, p.124-130 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 130 |
|---|---|
| container_issue | |
| container_start_page | 124 |
| container_title | International journal of psychophysiology |
| container_volume | 131 |
| creator | Milrad, Sara F. Hall, Daniel L. Jutagir, Devika R. Lattie, Emily G. Czaja, Sara J. Perdomo, Dolores M. Fletcher, Mary Ann Klimas, Nancy Antoni, Michael H. |
| description | Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and depression. Since depression is known to be associated with HPA axis dysfunction and greater inflammation, a psychoneuroendocrinological (PNE) model of inflammation was examined in persons diagnosed with CFS in order to uncover underlying biopsychosocial mechanisms in this poorly understood chronic illness.
Baseline data were drawn from two randomized controlled trials testing the efficacy of different forms of psychosocial intervention, and included psychological questionnaires, di-urnal salivary cortisol, and blood samples. Data were analyzed with structural equation modeling (SEM).
The sample (N=265) was mostly middle-aged (Mage=49.36±10.9, range=20–73years), Caucasian (67.7%), female (81.7%), highly educated (85.5% completed some college, college, or graduate program), and depressed (CES-D M=23.87±12.02, range 2–57). The SEM supporting a psychoneuroendocrinological model of immune dysregulation in CFS fit the data χ2 (12)=17.725, p=0.1243, RMSEA=0.043, CFI=0.935, SRMR=0.036. Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (β=0.215, p |
| doi_str_mv | 10.1016/j.ijpsycho.2017.09.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5851813</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167876017301629</els_id><sourcerecordid>1940198839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-497fbcccffa8dba4c6e63000d6ccc204889b0994defcff1fd1050a2ac439c69a3</originalsourceid><addsrcrecordid>eNqFkctu1DAUhi0EotPCK1ResiDBTjKxzQJRlXKRKrGBteU5Psl45NiDnYw0D8E742qmFaxY2T7-zn8uPyHXnNWc8f7drna7fT7CNtYN46JmqmZMPSMrLkVTiV6J52RVQFFJ0bMLcpnzjjEmuFIvyUUjFZeciRX5_Qn3CXN2MbyleMDgwkiz8e5g0pFCTLPL0VMTLHVh8GaazFzY8qCwTTE4oEOJjAvSfAw2xQnf0xt6ai3gkiIGGyG5EH0cHRhP85wWmJdUrgnHc3E6RYv-FXkxGJ_x9fm8Ij8_3_24_Vrdf__y7fbmvoJ1K-aqU2LYAMAwGGk3poMe-7ZMZ_sSbFgnpdowpTqLQ2H4YDlbM9MY6FoFvTLtFflw0t0vmwktYJhLO3qf3FTG1tE4_e9PcFs9xoNey3VZXFsE3pwFUvy1YJ715DKg9yZgXLLmqmNcSdmqgvYnFFLMOeHwVIYz_eCl3ulHL_WDl5opXbwsidd_N_mU9mheAT6eACyrOjhMOoPDAGhdQpi1je5_Nf4APTe7rA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1940198839</pqid></control><display><type>article</type><title>Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Milrad, Sara F. ; Hall, Daniel L. ; Jutagir, Devika R. ; Lattie, Emily G. ; Czaja, Sara J. ; Perdomo, Dolores M. ; Fletcher, Mary Ann ; Klimas, Nancy ; Antoni, Michael H.</creator><creatorcontrib>Milrad, Sara F. ; Hall, Daniel L. ; Jutagir, Devika R. ; Lattie, Emily G. ; Czaja, Sara J. ; Perdomo, Dolores M. ; Fletcher, Mary Ann ; Klimas, Nancy ; Antoni, Michael H.</creatorcontrib><description>Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and depression. Since depression is known to be associated with HPA axis dysfunction and greater inflammation, a psychoneuroendocrinological (PNE) model of inflammation was examined in persons diagnosed with CFS in order to uncover underlying biopsychosocial mechanisms in this poorly understood chronic illness.
Baseline data were drawn from two randomized controlled trials testing the efficacy of different forms of psychosocial intervention, and included psychological questionnaires, di-urnal salivary cortisol, and blood samples. Data were analyzed with structural equation modeling (SEM).
The sample (N=265) was mostly middle-aged (Mage=49.36±10.9, range=20–73years), Caucasian (67.7%), female (81.7%), highly educated (85.5% completed some college, college, or graduate program), and depressed (CES-D M=23.87±12.02, range 2–57). The SEM supporting a psychoneuroendocrinological model of immune dysregulation in CFS fit the data χ2 (12)=17.725, p=0.1243, RMSEA=0.043, CFI=0.935, SRMR=0.036. Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (β=0.215, p<0.01) and higher pro-inflammatory cytokines (interleukin-2 [IL-2], IL-6, and tumor necrosis factor-alpha [TNF-α] levels (β=0.185, p<0.05), when controlling for covariates.
Results highlight the role of depression, cortisol and inflammation in possible biological mechanisms involved in the pathophysiology of CFS. Time-lagged, longitudinal analyses are needed to fully explore these relationships.
•A structural regression model of chronic fatigue syndrome (CFS) is presented.•The psychoneuroendocrinological model of immune dysregulation in CFS fit the data.•Results highlight the role of depression, cortisol and inflammation in CFS.</description><identifier>ISSN: 0167-8760</identifier><identifier>EISSN: 1872-7697</identifier><identifier>DOI: 10.1016/j.ijpsycho.2017.09.009</identifier><identifier>PMID: 28918107</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Chronic fatigue syndrome (CFS) ; Depression ; Depression - etiology ; Evening cortisol ; Fatigue Syndrome, Chronic - complications ; Fatigue Syndrome, Chronic - metabolism ; Female ; Humans ; Hydrocortisone - metabolism ; Inflammation ; Inflammation - etiology ; Male ; Middle Aged ; Photoperiod ; Regression Analysis ; Saliva - metabolism ; Structural equation modeling ; Young Adult</subject><ispartof>International journal of psychophysiology, 2018-09, Vol.131, p.124-130</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-497fbcccffa8dba4c6e63000d6ccc204889b0994defcff1fd1050a2ac439c69a3</citedby><cites>FETCH-LOGICAL-c537t-497fbcccffa8dba4c6e63000d6ccc204889b0994defcff1fd1050a2ac439c69a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167876017301629$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28918107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Milrad, Sara F.</creatorcontrib><creatorcontrib>Hall, Daniel L.</creatorcontrib><creatorcontrib>Jutagir, Devika R.</creatorcontrib><creatorcontrib>Lattie, Emily G.</creatorcontrib><creatorcontrib>Czaja, Sara J.</creatorcontrib><creatorcontrib>Perdomo, Dolores M.</creatorcontrib><creatorcontrib>Fletcher, Mary Ann</creatorcontrib><creatorcontrib>Klimas, Nancy</creatorcontrib><creatorcontrib>Antoni, Michael H.</creatorcontrib><title>Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model</title><title>International journal of psychophysiology</title><addtitle>Int J Psychophysiol</addtitle><description>Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and depression. Since depression is known to be associated with HPA axis dysfunction and greater inflammation, a psychoneuroendocrinological (PNE) model of inflammation was examined in persons diagnosed with CFS in order to uncover underlying biopsychosocial mechanisms in this poorly understood chronic illness.
Baseline data were drawn from two randomized controlled trials testing the efficacy of different forms of psychosocial intervention, and included psychological questionnaires, di-urnal salivary cortisol, and blood samples. Data were analyzed with structural equation modeling (SEM).
The sample (N=265) was mostly middle-aged (Mage=49.36±10.9, range=20–73years), Caucasian (67.7%), female (81.7%), highly educated (85.5% completed some college, college, or graduate program), and depressed (CES-D M=23.87±12.02, range 2–57). The SEM supporting a psychoneuroendocrinological model of immune dysregulation in CFS fit the data χ2 (12)=17.725, p=0.1243, RMSEA=0.043, CFI=0.935, SRMR=0.036. Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (β=0.215, p<0.01) and higher pro-inflammatory cytokines (interleukin-2 [IL-2], IL-6, and tumor necrosis factor-alpha [TNF-α] levels (β=0.185, p<0.05), when controlling for covariates.
Results highlight the role of depression, cortisol and inflammation in possible biological mechanisms involved in the pathophysiology of CFS. Time-lagged, longitudinal analyses are needed to fully explore these relationships.
•A structural regression model of chronic fatigue syndrome (CFS) is presented.•The psychoneuroendocrinological model of immune dysregulation in CFS fit the data.•Results highlight the role of depression, cortisol and inflammation in CFS.</description><subject>Adult</subject><subject>Aged</subject><subject>Chronic fatigue syndrome (CFS)</subject><subject>Depression</subject><subject>Depression - etiology</subject><subject>Evening cortisol</subject><subject>Fatigue Syndrome, Chronic - complications</subject><subject>Fatigue Syndrome, Chronic - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Photoperiod</subject><subject>Regression Analysis</subject><subject>Saliva - metabolism</subject><subject>Structural equation modeling</subject><subject>Young Adult</subject><issn>0167-8760</issn><issn>1872-7697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi0EotPCK1ResiDBTjKxzQJRlXKRKrGBteU5Psl45NiDnYw0D8E742qmFaxY2T7-zn8uPyHXnNWc8f7drna7fT7CNtYN46JmqmZMPSMrLkVTiV6J52RVQFFJ0bMLcpnzjjEmuFIvyUUjFZeciRX5_Qn3CXN2MbyleMDgwkiz8e5g0pFCTLPL0VMTLHVh8GaazFzY8qCwTTE4oEOJjAvSfAw2xQnf0xt6ai3gkiIGGyG5EH0cHRhP85wWmJdUrgnHc3E6RYv-FXkxGJ_x9fm8Ij8_3_24_Vrdf__y7fbmvoJ1K-aqU2LYAMAwGGk3poMe-7ZMZ_sSbFgnpdowpTqLQ2H4YDlbM9MY6FoFvTLtFflw0t0vmwktYJhLO3qf3FTG1tE4_e9PcFs9xoNey3VZXFsE3pwFUvy1YJ715DKg9yZgXLLmqmNcSdmqgvYnFFLMOeHwVIYz_eCl3ulHL_WDl5opXbwsidd_N_mU9mheAT6eACyrOjhMOoPDAGhdQpi1je5_Nf4APTe7rA</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Milrad, Sara F.</creator><creator>Hall, Daniel L.</creator><creator>Jutagir, Devika R.</creator><creator>Lattie, Emily G.</creator><creator>Czaja, Sara J.</creator><creator>Perdomo, Dolores M.</creator><creator>Fletcher, Mary Ann</creator><creator>Klimas, Nancy</creator><creator>Antoni, Michael H.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180901</creationdate><title>Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model</title><author>Milrad, Sara F. ; Hall, Daniel L. ; Jutagir, Devika R. ; Lattie, Emily G. ; Czaja, Sara J. ; Perdomo, Dolores M. ; Fletcher, Mary Ann ; Klimas, Nancy ; Antoni, Michael H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-497fbcccffa8dba4c6e63000d6ccc204889b0994defcff1fd1050a2ac439c69a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Chronic fatigue syndrome (CFS)</topic><topic>Depression</topic><topic>Depression - etiology</topic><topic>Evening cortisol</topic><topic>Fatigue Syndrome, Chronic - complications</topic><topic>Fatigue Syndrome, Chronic - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Photoperiod</topic><topic>Regression Analysis</topic><topic>Saliva - metabolism</topic><topic>Structural equation modeling</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Milrad, Sara F.</creatorcontrib><creatorcontrib>Hall, Daniel L.</creatorcontrib><creatorcontrib>Jutagir, Devika R.</creatorcontrib><creatorcontrib>Lattie, Emily G.</creatorcontrib><creatorcontrib>Czaja, Sara J.</creatorcontrib><creatorcontrib>Perdomo, Dolores M.</creatorcontrib><creatorcontrib>Fletcher, Mary Ann</creatorcontrib><creatorcontrib>Klimas, Nancy</creatorcontrib><creatorcontrib>Antoni, Michael H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of psychophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Milrad, Sara F.</au><au>Hall, Daniel L.</au><au>Jutagir, Devika R.</au><au>Lattie, Emily G.</au><au>Czaja, Sara J.</au><au>Perdomo, Dolores M.</au><au>Fletcher, Mary Ann</au><au>Klimas, Nancy</au><au>Antoni, Michael H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model</atitle><jtitle>International journal of psychophysiology</jtitle><addtitle>Int J Psychophysiol</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>131</volume><spage>124</spage><epage>130</epage><pages>124-130</pages><issn>0167-8760</issn><eissn>1872-7697</eissn><abstract>Chronic Fatigue Syndrome (CFS) is a poorly understood illness that is characterized by diverse somatic symptoms, hypothalamic pituitary adrenal (HPA) axis dysfunction and heightened inflammatory indicators. These symptoms are often exacerbated and accompanied by psychological distress states and depression. Since depression is known to be associated with HPA axis dysfunction and greater inflammation, a psychoneuroendocrinological (PNE) model of inflammation was examined in persons diagnosed with CFS in order to uncover underlying biopsychosocial mechanisms in this poorly understood chronic illness.
Baseline data were drawn from two randomized controlled trials testing the efficacy of different forms of psychosocial intervention, and included psychological questionnaires, di-urnal salivary cortisol, and blood samples. Data were analyzed with structural equation modeling (SEM).
The sample (N=265) was mostly middle-aged (Mage=49.36±10.9, range=20–73years), Caucasian (67.7%), female (81.7%), highly educated (85.5% completed some college, college, or graduate program), and depressed (CES-D M=23.87±12.02, range 2–57). The SEM supporting a psychoneuroendocrinological model of immune dysregulation in CFS fit the data χ2 (12)=17.725, p=0.1243, RMSEA=0.043, CFI=0.935, SRMR=0.036. Depression was directly related to evening salivary cortisol and inflammation, such that higher evening cortisol predicted greater depressive symptoms (β=0.215, p<0.01) and higher pro-inflammatory cytokines (interleukin-2 [IL-2], IL-6, and tumor necrosis factor-alpha [TNF-α] levels (β=0.185, p<0.05), when controlling for covariates.
Results highlight the role of depression, cortisol and inflammation in possible biological mechanisms involved in the pathophysiology of CFS. Time-lagged, longitudinal analyses are needed to fully explore these relationships.
•A structural regression model of chronic fatigue syndrome (CFS) is presented.•The psychoneuroendocrinological model of immune dysregulation in CFS fit the data.•Results highlight the role of depression, cortisol and inflammation in CFS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28918107</pmid><doi>10.1016/j.ijpsycho.2017.09.009</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-8760 |
| ispartof | International journal of psychophysiology, 2018-09, Vol.131, p.124-130 |
| issn | 0167-8760 1872-7697 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5851813 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Chronic fatigue syndrome (CFS) Depression Depression - etiology Evening cortisol Fatigue Syndrome, Chronic - complications Fatigue Syndrome, Chronic - metabolism Female Humans Hydrocortisone - metabolism Inflammation Inflammation - etiology Male Middle Aged Photoperiod Regression Analysis Saliva - metabolism Structural equation modeling Young Adult |
| title | Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A46%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Depression,%20evening%20salivary%20cortisol%20and%20inflammation%20in%20chronic%20fatigue%20syndrome:%20A%20psychoneuroendocrinological%20structural%20regression%20model&rft.jtitle=International%20journal%20of%20psychophysiology&rft.au=Milrad,%20Sara%20F.&rft.date=2018-09-01&rft.volume=131&rft.spage=124&rft.epage=130&rft.pages=124-130&rft.issn=0167-8760&rft.eissn=1872-7697&rft_id=info:doi/10.1016/j.ijpsycho.2017.09.009&rft_dat=%3Cproquest_pubme%3E1940198839%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1940198839&rft_id=info:pmid/28918107&rft_els_id=S0167876017301629&rfr_iscdi=true |