Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children

Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk facto...

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Veröffentlicht in:Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-9
Hauptverfasser: Sztefko, Krystyna, Drożdż, Tomasz, Łątka, Monika, Drożdż, Dorota, Kwinta, Przemko
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container_issue 2018
container_start_page 1
container_title Oxidative medicine and cellular longevity
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creator Sztefko, Krystyna
Drożdż, Tomasz
Łątka, Monika
Drożdż, Dorota
Kwinta, Przemko
description Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p
doi_str_mv 10.1155/2018/1619293
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The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p&lt;0.001), cystatin C (R=0.738; p&lt;0.001), BNP (R=0.406; p=0.001), ADMA (R=0.353; p=0.01), oxLDL (R=0.340; p=0.009), 24-hour systolic (R=0.345; p=0.011) and mean (R=0.315; p&lt;0.05) BP values, and left ventricular mass index (LVMI, R=0.293; p=0.024) and negatively with estimated glomerular filtration rate (R=−0.716; p&lt;0.001). In children with CKD, TM strongly depended on kidney function parameters, oxLDL levels, and 24-hour systolic and mean BP values. Thrombomodulin seems to be a valuable marker of ED in CKD patients, correlating with CKD stage as well as oxidative stress, BP values, and LVMI.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2018/1619293</identifier><identifier>PMID: 29682152</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Atherosclerosis ; Biomarkers ; Blood Pressure - physiology ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiac patients ; Cardiovascular disease ; Cardiovascular diseases ; Child ; Child, Preschool ; Children ; Children &amp; youth ; Chronic kidney failure ; Clinical trials ; Creatinine - blood ; Cystatin C - blood ; Diabetes ; Diseases ; Echocardiography ; Endothelium ; Ethylenediaminetetraacetic acid ; Female ; Glomerular Filtration Rate - physiology ; Glycoproteins ; Health aspects ; Health risk assessment ; Heart ; Humans ; Infant ; Kidney diseases ; Low density lipoproteins ; Male ; Medical research ; Medicine, Experimental ; Mortality ; Natriuretic peptides ; Nephrology ; Nitric oxide ; Oxidation ; Oxidative stress ; Pediatrics ; Proteins ; Renal Insufficiency, Chronic - blood ; Risk factors ; Thrombomodulin - blood ; Thrombosis ; Urine ; Von Willebrand factor</subject><ispartof>Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-9</ispartof><rights>Copyright © 2018 Dorota Drożdż et al.</rights><rights>COPYRIGHT 2018 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2018 Dorota Drożdż et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Dorota Drożdż et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-b90c098396dbeb6e13548340a939579d93570ff3313e336eedcf47f52aa402493</citedby><cites>FETCH-LOGICAL-c565t-b90c098396dbeb6e13548340a939579d93570ff3313e336eedcf47f52aa402493</cites><orcidid>0000-0001-8852-4498 ; 0000-0001-5602-1300 ; 0000-0002-3017-0348 ; 0000-0002-1281-1164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851028/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851028/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29682152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kwapiszewska, Grazyna</contributor><contributor>Grazyna Kwapiszewska</contributor><creatorcontrib>Sztefko, Krystyna</creatorcontrib><creatorcontrib>Drożdż, Tomasz</creatorcontrib><creatorcontrib>Łątka, Monika</creatorcontrib><creatorcontrib>Drożdż, Dorota</creatorcontrib><creatorcontrib>Kwinta, Przemko</creatorcontrib><title>Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p&lt;0.001), cystatin C (R=0.738; p&lt;0.001), BNP (R=0.406; p=0.001), ADMA (R=0.353; p=0.01), oxLDL (R=0.340; p=0.009), 24-hour systolic (R=0.345; p=0.011) and mean (R=0.315; p&lt;0.05) BP values, and left ventricular mass index (LVMI, R=0.293; p=0.024) and negatively with estimated glomerular filtration rate (R=−0.716; p&lt;0.001). In children with CKD, TM strongly depended on kidney function parameters, oxLDL levels, and 24-hour systolic and mean BP values. Thrombomodulin seems to be a valuable marker of ED in CKD patients, correlating with CKD stage as well as oxidative stress, BP values, and LVMI.</description><subject>Adolescent</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Blood Pressure - physiology</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiac patients</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children &amp; youth</subject><subject>Chronic kidney failure</subject><subject>Clinical trials</subject><subject>Creatinine - blood</subject><subject>Cystatin C - blood</subject><subject>Diabetes</subject><subject>Diseases</subject><subject>Echocardiography</subject><subject>Endothelium</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Glycoproteins</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Humans</subject><subject>Infant</subject><subject>Kidney diseases</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Natriuretic peptides</subject><subject>Nephrology</subject><subject>Nitric oxide</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Risk factors</subject><subject>Thrombomodulin - blood</subject><subject>Thrombosis</subject><subject>Urine</subject><subject>Von Willebrand factor</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1v1DAQhiMEoqVw44wscUGiS8dfiX1BqrYtIApcytlyknHXJbFbO6Haf49Xu2yBEydbmsfPzPitqpcU3lEq5QkDqk5oTTXT_FF1SLVgC9BaPN7fAQ6qZznfANScCfq0OmC6VoxKdliZq1WKYxvH2M-DD8RmYslXvCdfbPqBiURHzkMfpxUO3g7kbJ3dHLrJx0AKvSyPg-_IZ98HXJMzn9Fm3Fb80CcMz6snzg4ZX-zOo-r7xfnV8uPi8tuHT8vTy0UnazktWg0daMV13bfY1ki5FIoLsJpr2ehec9mAc5xTjpzXiH3nROMks1YAE5ofVe-33tu5HUsVw5TsYG6TH21am2i9-bsS_Mpcx59GKkmBqSJ4sxOkeDdjnszoc4fDYAPGORsG5dM4b0AW9PU_6E2cUyjrFYoyJQQAe6Cu7YDGBxdL324jNac1sIY2Um3aHm-pLsWcE7r9yBTMJt-NUpldvgV_9eeae_h3oAV4uwVWPvT23v-nDguDzj7QjILSjP8C7he1DQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Sztefko, Krystyna</creator><creator>Drożdż, Tomasz</creator><creator>Łątka, Monika</creator><creator>Drożdż, Dorota</creator><creator>Kwinta, Przemko</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; 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The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p&lt;0.001), cystatin C (R=0.738; p&lt;0.001), BNP (R=0.406; p=0.001), ADMA (R=0.353; p=0.01), oxLDL (R=0.340; p=0.009), 24-hour systolic (R=0.345; p=0.011) and mean (R=0.315; p&lt;0.05) BP values, and left ventricular mass index (LVMI, R=0.293; p=0.024) and negatively with estimated glomerular filtration rate (R=−0.716; p&lt;0.001). In children with CKD, TM strongly depended on kidney function parameters, oxLDL levels, and 24-hour systolic and mean BP values. Thrombomodulin seems to be a valuable marker of ED in CKD patients, correlating with CKD stage as well as oxidative stress, BP values, and LVMI.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29682152</pmid><doi>10.1155/2018/1619293</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8852-4498</orcidid><orcidid>https://orcid.org/0000-0001-5602-1300</orcidid><orcidid>https://orcid.org/0000-0002-3017-0348</orcidid><orcidid>https://orcid.org/0000-0002-1281-1164</orcidid><oa>free_for_read</oa></addata></record>
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection
subjects Adolescent
Atherosclerosis
Biomarkers
Blood Pressure - physiology
C-reactive protein
C-Reactive Protein - metabolism
Cardiac patients
Cardiovascular disease
Cardiovascular diseases
Child
Child, Preschool
Children
Children & youth
Chronic kidney failure
Clinical trials
Creatinine - blood
Cystatin C - blood
Diabetes
Diseases
Echocardiography
Endothelium
Ethylenediaminetetraacetic acid
Female
Glomerular Filtration Rate - physiology
Glycoproteins
Health aspects
Health risk assessment
Heart
Humans
Infant
Kidney diseases
Low density lipoproteins
Male
Medical research
Medicine, Experimental
Mortality
Natriuretic peptides
Nephrology
Nitric oxide
Oxidation
Oxidative stress
Pediatrics
Proteins
Renal Insufficiency, Chronic - blood
Risk factors
Thrombomodulin - blood
Thrombosis
Urine
Von Willebrand factor
title Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children
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