Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children
Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk facto...
Gespeichert in:
Veröffentlicht in: | Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-9 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 9 |
---|---|
container_issue | 2018 |
container_start_page | 1 |
container_title | Oxidative medicine and cellular longevity |
container_volume | 2018 |
creator | Sztefko, Krystyna Drożdż, Tomasz Łątka, Monika Drożdż, Dorota Kwinta, Przemko |
description | Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p |
doi_str_mv | 10.1155/2018/1619293 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5851028</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A602717588</galeid><sourcerecordid>A602717588</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-b90c098396dbeb6e13548340a939579d93570ff3313e336eedcf47f52aa402493</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhiMEoqVw44wscUGiS8dfiX1BqrYtIApcytlyknHXJbFbO6Haf49Xu2yBEydbmsfPzPitqpcU3lEq5QkDqk5oTTXT_FF1SLVgC9BaPN7fAQ6qZznfANScCfq0OmC6VoxKdliZq1WKYxvH2M-DD8RmYslXvCdfbPqBiURHzkMfpxUO3g7kbJ3dHLrJx0AKvSyPg-_IZ98HXJMzn9Fm3Fb80CcMz6snzg4ZX-zOo-r7xfnV8uPi8tuHT8vTy0UnazktWg0daMV13bfY1ki5FIoLsJpr2ehec9mAc5xTjpzXiH3nROMks1YAE5ofVe-33tu5HUsVw5TsYG6TH21am2i9-bsS_Mpcx59GKkmBqSJ4sxOkeDdjnszoc4fDYAPGORsG5dM4b0AW9PU_6E2cUyjrFYoyJQQAe6Cu7YDGBxdL324jNac1sIY2Um3aHm-pLsWcE7r9yBTMJt-NUpldvgV_9eeae_h3oAV4uwVWPvT23v-nDguDzj7QjILSjP8C7he1DQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2012844002</pqid></control><display><type>article</type><title>Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Sztefko, Krystyna ; Drożdż, Tomasz ; Łątka, Monika ; Drożdż, Dorota ; Kwinta, Przemko</creator><contributor>Kwapiszewska, Grazyna ; Grazyna Kwapiszewska</contributor><creatorcontrib>Sztefko, Krystyna ; Drożdż, Tomasz ; Łątka, Monika ; Drożdż, Dorota ; Kwinta, Przemko ; Kwapiszewska, Grazyna ; Grazyna Kwapiszewska</creatorcontrib><description>Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p<0.001), cystatin C (R=0.738; p<0.001), BNP (R=0.406; p=0.001), ADMA (R=0.353; p=0.01), oxLDL (R=0.340; p=0.009), 24-hour systolic (R=0.345; p=0.011) and mean (R=0.315; p<0.05) BP values, and left ventricular mass index (LVMI, R=0.293; p=0.024) and negatively with estimated glomerular filtration rate (R=−0.716; p<0.001). In children with CKD, TM strongly depended on kidney function parameters, oxLDL levels, and 24-hour systolic and mean BP values. Thrombomodulin seems to be a valuable marker of ED in CKD patients, correlating with CKD stage as well as oxidative stress, BP values, and LVMI.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2018/1619293</identifier><identifier>PMID: 29682152</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Atherosclerosis ; Biomarkers ; Blood Pressure - physiology ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiac patients ; Cardiovascular disease ; Cardiovascular diseases ; Child ; Child, Preschool ; Children ; Children & youth ; Chronic kidney failure ; Clinical trials ; Creatinine - blood ; Cystatin C - blood ; Diabetes ; Diseases ; Echocardiography ; Endothelium ; Ethylenediaminetetraacetic acid ; Female ; Glomerular Filtration Rate - physiology ; Glycoproteins ; Health aspects ; Health risk assessment ; Heart ; Humans ; Infant ; Kidney diseases ; Low density lipoproteins ; Male ; Medical research ; Medicine, Experimental ; Mortality ; Natriuretic peptides ; Nephrology ; Nitric oxide ; Oxidation ; Oxidative stress ; Pediatrics ; Proteins ; Renal Insufficiency, Chronic - blood ; Risk factors ; Thrombomodulin - blood ; Thrombosis ; Urine ; Von Willebrand factor</subject><ispartof>Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-9</ispartof><rights>Copyright © 2018 Dorota Drożdż et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Dorota Drożdż et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Dorota Drożdż et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-b90c098396dbeb6e13548340a939579d93570ff3313e336eedcf47f52aa402493</citedby><cites>FETCH-LOGICAL-c565t-b90c098396dbeb6e13548340a939579d93570ff3313e336eedcf47f52aa402493</cites><orcidid>0000-0001-8852-4498 ; 0000-0001-5602-1300 ; 0000-0002-3017-0348 ; 0000-0002-1281-1164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851028/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851028/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29682152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kwapiszewska, Grazyna</contributor><contributor>Grazyna Kwapiszewska</contributor><creatorcontrib>Sztefko, Krystyna</creatorcontrib><creatorcontrib>Drożdż, Tomasz</creatorcontrib><creatorcontrib>Łątka, Monika</creatorcontrib><creatorcontrib>Drożdż, Dorota</creatorcontrib><creatorcontrib>Kwinta, Przemko</creatorcontrib><title>Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p<0.001), cystatin C (R=0.738; p<0.001), BNP (R=0.406; p=0.001), ADMA (R=0.353; p=0.01), oxLDL (R=0.340; p=0.009), 24-hour systolic (R=0.345; p=0.011) and mean (R=0.315; p<0.05) BP values, and left ventricular mass index (LVMI, R=0.293; p=0.024) and negatively with estimated glomerular filtration rate (R=−0.716; p<0.001). In children with CKD, TM strongly depended on kidney function parameters, oxLDL levels, and 24-hour systolic and mean BP values. Thrombomodulin seems to be a valuable marker of ED in CKD patients, correlating with CKD stage as well as oxidative stress, BP values, and LVMI.</description><subject>Adolescent</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Blood Pressure - physiology</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiac patients</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Chronic kidney failure</subject><subject>Clinical trials</subject><subject>Creatinine - blood</subject><subject>Cystatin C - blood</subject><subject>Diabetes</subject><subject>Diseases</subject><subject>Echocardiography</subject><subject>Endothelium</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Glycoproteins</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Heart</subject><subject>Humans</subject><subject>Infant</subject><subject>Kidney diseases</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Natriuretic peptides</subject><subject>Nephrology</subject><subject>Nitric oxide</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Risk factors</subject><subject>Thrombomodulin - blood</subject><subject>Thrombosis</subject><subject>Urine</subject><subject>Von Willebrand factor</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1v1DAQhiMEoqVw44wscUGiS8dfiX1BqrYtIApcytlyknHXJbFbO6Haf49Xu2yBEydbmsfPzPitqpcU3lEq5QkDqk5oTTXT_FF1SLVgC9BaPN7fAQ6qZznfANScCfq0OmC6VoxKdliZq1WKYxvH2M-DD8RmYslXvCdfbPqBiURHzkMfpxUO3g7kbJ3dHLrJx0AKvSyPg-_IZ98HXJMzn9Fm3Fb80CcMz6snzg4ZX-zOo-r7xfnV8uPi8tuHT8vTy0UnazktWg0daMV13bfY1ki5FIoLsJpr2ehec9mAc5xTjpzXiH3nROMks1YAE5ofVe-33tu5HUsVw5TsYG6TH21am2i9-bsS_Mpcx59GKkmBqSJ4sxOkeDdjnszoc4fDYAPGORsG5dM4b0AW9PU_6E2cUyjrFYoyJQQAe6Cu7YDGBxdL324jNac1sIY2Um3aHm-pLsWcE7r9yBTMJt-NUpldvgV_9eeae_h3oAV4uwVWPvT23v-nDguDzj7QjILSjP8C7he1DQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Sztefko, Krystyna</creator><creator>Drożdż, Tomasz</creator><creator>Łątka, Monika</creator><creator>Drożdż, Dorota</creator><creator>Kwinta, Przemko</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8852-4498</orcidid><orcidid>https://orcid.org/0000-0001-5602-1300</orcidid><orcidid>https://orcid.org/0000-0002-3017-0348</orcidid><orcidid>https://orcid.org/0000-0002-1281-1164</orcidid></search><sort><creationdate>20180101</creationdate><title>Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children</title><author>Sztefko, Krystyna ; Drożdż, Tomasz ; Łątka, Monika ; Drożdż, Dorota ; Kwinta, Przemko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-b90c098396dbeb6e13548340a939579d93570ff3313e336eedcf47f52aa402493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Blood Pressure - physiology</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiac patients</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Chronic kidney failure</topic><topic>Clinical trials</topic><topic>Creatinine - blood</topic><topic>Cystatin C - blood</topic><topic>Diabetes</topic><topic>Diseases</topic><topic>Echocardiography</topic><topic>Endothelium</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Female</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Glycoproteins</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Heart</topic><topic>Humans</topic><topic>Infant</topic><topic>Kidney diseases</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Natriuretic peptides</topic><topic>Nephrology</topic><topic>Nitric oxide</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Pediatrics</topic><topic>Proteins</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Risk factors</topic><topic>Thrombomodulin - blood</topic><topic>Thrombosis</topic><topic>Urine</topic><topic>Von Willebrand factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sztefko, Krystyna</creatorcontrib><creatorcontrib>Drożdż, Tomasz</creatorcontrib><creatorcontrib>Łątka, Monika</creatorcontrib><creatorcontrib>Drożdż, Dorota</creatorcontrib><creatorcontrib>Kwinta, Przemko</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sztefko, Krystyna</au><au>Drożdż, Tomasz</au><au>Łątka, Monika</au><au>Drożdż, Dorota</au><au>Kwinta, Przemko</au><au>Kwapiszewska, Grazyna</au><au>Grazyna Kwapiszewska</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Endothelial dysfunction (ED) and oxidative stress are potential new pathomechanisms of cardiovascular diseases in patients with chronic kidney disease (CKD). The aim of the study was to assess the association between endothelial dysfunction, oxidative stress biomarkers, and cardiovascular risk factors in children with CKD. Serum oxidized LDL (oxLDL), protein carbonyl group, urea, creatinine, cystatin C, thrombomodulin, asymmetric dimethylarginine (ADMA), von Willebrand factor, brain natriuretic peptide (BNP), lipids, high sensitivity C-reactive protein, intercellular adhesion molecule-1 levels, and albuminuria were measured. Anthropometric, ambulatory blood pressure (BP) measurements and echocardiography were performed. The studied group consisted of 59 patients aged 0.7–18.6 (mean 11.1) years with stages 1 to 5 CKD. Thrombomodulin strongly correlated with creatinine (R=0.666; p<0.001), cystatin C (R=0.738; p<0.001), BNP (R=0.406; p=0.001), ADMA (R=0.353; p=0.01), oxLDL (R=0.340; p=0.009), 24-hour systolic (R=0.345; p=0.011) and mean (R=0.315; p<0.05) BP values, and left ventricular mass index (LVMI, R=0.293; p=0.024) and negatively with estimated glomerular filtration rate (R=−0.716; p<0.001). In children with CKD, TM strongly depended on kidney function parameters, oxLDL levels, and 24-hour systolic and mean BP values. Thrombomodulin seems to be a valuable marker of ED in CKD patients, correlating with CKD stage as well as oxidative stress, BP values, and LVMI.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29682152</pmid><doi>10.1155/2018/1619293</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8852-4498</orcidid><orcidid>https://orcid.org/0000-0001-5602-1300</orcidid><orcidid>https://orcid.org/0000-0002-3017-0348</orcidid><orcidid>https://orcid.org/0000-0002-1281-1164</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1942-0900 |
ispartof | Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-9 |
issn | 1942-0900 1942-0994 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5851028 |
source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
subjects | Adolescent Atherosclerosis Biomarkers Blood Pressure - physiology C-reactive protein C-Reactive Protein - metabolism Cardiac patients Cardiovascular disease Cardiovascular diseases Child Child, Preschool Children Children & youth Chronic kidney failure Clinical trials Creatinine - blood Cystatin C - blood Diabetes Diseases Echocardiography Endothelium Ethylenediaminetetraacetic acid Female Glomerular Filtration Rate - physiology Glycoproteins Health aspects Health risk assessment Heart Humans Infant Kidney diseases Low density lipoproteins Male Medical research Medicine, Experimental Mortality Natriuretic peptides Nephrology Nitric oxide Oxidation Oxidative stress Pediatrics Proteins Renal Insufficiency, Chronic - blood Risk factors Thrombomodulin - blood Thrombosis Urine Von Willebrand factor |
title | Thrombomodulin as a New Marker of Endothelial Dysfunction in Chronic Kidney Disease in Children |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T17%3A39%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thrombomodulin%20as%20a%20New%20Marker%20of%20Endothelial%20Dysfunction%20in%20Chronic%20Kidney%20Disease%20in%20Children&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Sztefko,%20Krystyna&rft.date=2018-01-01&rft.volume=2018&rft.issue=2018&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2018/1619293&rft_dat=%3Cgale_pubme%3EA602717588%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2012844002&rft_id=info:pmid/29682152&rft_galeid=A602717588&rfr_iscdi=true |