A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity. Gut bacterial pharmacy The human microbiome has a substantial effect on o...

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Veröffentlicht in:	Nature (London) 2017-11, Vol.551 (7682), p.648-652
Hauptverfasser:	Dodd, Dylan, Spitzer, Matthew H., Van Treuren, William, Merrill, Bryan D., Hryckowian, Andrew J., Higginbottom, Steven K., Le, Anthony, Cowan, Tina M., Nolan, Garry P., Fischbach, Michael A., Sonnenburg, Justin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 45 45/41 45/44 631/326/2565/2134 631/45/320 64/60 82/58 Amino acids Amino Acids, Aromatic - blood Amino Acids, Aromatic - metabolism Animals Bacteria Blood Chemical Analysis Closterium - genetics Closterium - metabolism Clostridium Digestive system Enzymes Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - physiology Gastrointestinal tract Genetic engineering Genetics Germ-Free Life Gnotobiotic Humanities and Social Sciences Humans Immunity Indoles - blood Indoles - metabolism Intestinal microflora Intestinal Mucosa - metabolism Intestine letter Male Metabolic Networks and Pathways - genetics Metabolic pathways Metabolism Metabolites Metabolome - physiology Metabolomics Mice Microbiota Microbiota (Symbiotic organisms) Microorganisms multidisciplinary Multigene Family - genetics Mutagenesis Permeability Phenylalanine Phenylalanine - metabolism Physiological aspects Reductases Science Serum - chemistry Serum - metabolism Serum levels Substrates Tryptophan Tryptophan - metabolism Tyrosine Tyrosine - metabolism
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