Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery
In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.
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| Veröffentlicht in: | Clinical infectious diseases 2017-10, Vol.65 (8), p.1400-1403 |
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| container_title | Clinical infectious diseases |
| container_volume | 65 |
| creator | Barnes, Kayla G. Kindrachuk, Jason Lin, Aaron E. Wohl, Shirlee Qu, James Tostenson, Samantha D. Dorman, William R. Busby, Michele Siddle, Katherine J. Luo, Cynthia Y. Matranga, Christian B. Davey, Richard T. Sabeti, Pardis C. Chertow, Daniel S. |
| description | In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen. |
| doi_str_mv | 10.1093/cid/cix518 |
| format | Article |
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Virus in semen is replication-competent with no change in viral genome over time. 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This work is written by (a) US Government employee(s) and is in the public domain in the US.</rights><rights>Copyright Oxford University Press, UK Oct 15, 2017</rights><rights>Published by Oxford University Press for the Infectious Diseases Society of America 2017. 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Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.</description><subject>Adult</subject><subject>BRIEF REPORTS</subject><subject>Ebola virus</subject><subject>Ebolavirus</subject><subject>Ebolavirus - classification</subject><subject>Ebolavirus - genetics</subject><subject>Genome, Viral - genetics</subject><subject>Genomes</subject><subject>Hemorrhagic Fever, Ebola - virology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Recovery</subject><subject>Replication</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA viruses</subject><subject>RNA, Viral - analysis</subject><subject>RNA, Viral - genetics</subject><subject>Semen</subject><subject>Semen - virology</subject><subject>Viral diseases</subject><subject>Viral Load</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1rFDEUxYNY7JcvvisBX4owNncyySQvBVlXKxQUv17j3Uxmm2U2WZOZxf73pkxbPx5Cwj2_ezjhEPIM2Gtgmp9b35XzS4B6RI5A8LaSQsPj8mZCVY3i6pAc57xhDEAx8YQc1kqoWgA_Ij-We9-5YB2NPV2u4oD0u09Tpp_dbvAWRx8DxdDRS7--potYyDCmeewD_eK2LtyuIv1UhkWjb6fkw7rs27h36eaUHPQ4ZPf07j4h394tvy4uq6uP7z8s3lxVtqnVWEGrkSnERoPrsO-lW9WMQ4NYawZ8BQqtltoKwJoLFNC0Auueub7TrbKKn5CL2Xc3rbaum2MOZpf8FtONiejNv0rw12Yd90YowQToYnB2Z5Diz8nl0Wx9tm4YMLg4ZQOayUa2CpqCvvwP3cQphfK9QknVMKmUKNSrmbIp5pxc_xAGmLktzpTizFxcgV_8Hf8BvW-qAM9nYJPHmP7okreilS3_DZWqnpw</recordid><startdate>20171015</startdate><enddate>20171015</enddate><creator>Barnes, Kayla G.</creator><creator>Kindrachuk, Jason</creator><creator>Lin, Aaron E.</creator><creator>Wohl, Shirlee</creator><creator>Qu, James</creator><creator>Tostenson, Samantha D.</creator><creator>Dorman, William R.</creator><creator>Busby, Michele</creator><creator>Siddle, Katherine J.</creator><creator>Luo, Cynthia Y.</creator><creator>Matranga, Christian B.</creator><creator>Davey, Richard T.</creator><creator>Sabeti, Pardis C.</creator><creator>Chertow, Daniel S.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171015</creationdate><title>Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery</title><author>Barnes, Kayla G. ; 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| ispartof | Clinical infectious diseases, 2017-10, Vol.65 (8), p.1400-1403 |
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| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult BRIEF REPORTS Ebola virus Ebolavirus Ebolavirus - classification Ebolavirus - genetics Genome, Viral - genetics Genomes Hemorrhagic Fever, Ebola - virology Humans Male Medical treatment Recovery Replication Ribonucleic acid RNA RNA viruses RNA, Viral - analysis RNA, Viral - genetics Semen Semen - virology Viral diseases Viral Load Viruses |
| title | Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery |
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