Evidence of Ebola Virus Replication and High Concentration in Semen of a Patient During Recovery

In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.

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Bibliographische Detailangaben
Veröffentlicht in:	Clinical infectious diseases 2017-10, Vol.65 (8), p.1400-1403
Hauptverfasser:	Barnes, Kayla G., Kindrachuk, Jason, Lin, Aaron E., Wohl, Shirlee, Qu, James, Tostenson, Samantha D., Dorman, William R., Busby, Michele, Siddle, Katherine J., Luo, Cynthia Y., Matranga, Christian B., Davey, Richard T., Sabeti, Pardis C., Chertow, Daniel S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult BRIEF REPORTS Ebola virus Ebolavirus Ebolavirus - classification Ebolavirus - genetics Genome, Viral - genetics Genomes Hemorrhagic Fever, Ebola - virology Humans Male Medical treatment Recovery Replication Ribonucleic acid RNA RNA viruses RNA, Viral - analysis RNA, Viral - genetics Semen Semen - virology Viral diseases Viral Load Viruses
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Beschreibung
Zusammenfassung:	In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cix518