Adult adiposity and risk of early menopause
Is adult adiposity associated with early menopause? Overall and abdominal adiposity were non-linearly associated with odds for early natural menopause with elevated odds observed among women who were underweight in early or mid-adulthood compared to lean-normal weight women. High and low adiposity h...
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| Veröffentlicht in: | Human reproduction (Oxford) 2017-12, Vol.32 (12), p.2522-2531 |
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| creator | Szegda, K L Whitcomb, B W Purdue-Smithe, A C Boutot, M E Manson, J E Hankinson, S E Rosner, B A Bertone-Johnson, E R |
| description | Is adult adiposity associated with early menopause?
Overall and abdominal adiposity were non-linearly associated with odds for early natural menopause with elevated odds observed among women who were underweight in early or mid-adulthood compared to lean-normal weight women.
High and low adiposity have been associated with reproductive function and may potentially impact timing of menopause. It is unclear whether various aspects of adiposity are associated with risk of early menopause.
Prospective cohort study that examined data from 78 759 premenopausal women from the Nurses' Health Study II who were followed from 1989 to 2011 for incidence of early natural menopause.
Participants were aged 25-42 years and premenopausal at baseline in 1989, when information on menopausal status, height and weight was reported via questionnaire. Information on menopausal status, type of menopause (natural, surgical, radiation/chemotherapy), hormone therapy use and weight was updated every two years along with information on smoking, physical activity and other behavioral and health-related factors. Multivariable logistic regression was used to estimate odds ratios for early menopause, defined as natural menopause before age 45 years, by aspects of adiposity.
Early natural menopause was reported by 2804 participants. Body mass index (BMI) was non-linearly associated with risk for early menopause. Compared to women with BMI = 18.5-22.4 kg/m2, those with BMI < 18.5 kg/m2 had a significant 30% higher odds of early menopause (95% confidence interval (CI) = 1.08, 1.57), while women with BMIs between 25.0-29.9 kg/m2 had significant 21-30% lower odds. Odds were not higher in women with BMI ≥ 35.0 kg/m2 in fully adjusted analysis. Non-linear associations with higher odds in underweight women were also observed for age 18 and age 35 BMI, though lower odds for overweight women was only observed for age 35 BMI. Odds were highest among women with age 18 BMI < 18.5 kg/m2 reporting severe weight cycling.
Though weight and early menopause status were self-reported, validation studies conducted among Nurses' Health Study participants suggest that self-reported weight is highly correlated with directly measured weight, and prospective self-reported menopausal status is highly reproducible. It is possible that underweight women may have been misclassified with an earlier age at menopause if being underweight led to amenorrhea.
In one of the few studies to prospectively examine a variety of a |
| doi_str_mv | 10.1093/humrep/dex304 |
| format | Article |
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Overall and abdominal adiposity were non-linearly associated with odds for early natural menopause with elevated odds observed among women who were underweight in early or mid-adulthood compared to lean-normal weight women.
High and low adiposity have been associated with reproductive function and may potentially impact timing of menopause. It is unclear whether various aspects of adiposity are associated with risk of early menopause.
Prospective cohort study that examined data from 78 759 premenopausal women from the Nurses' Health Study II who were followed from 1989 to 2011 for incidence of early natural menopause.
Participants were aged 25-42 years and premenopausal at baseline in 1989, when information on menopausal status, height and weight was reported via questionnaire. Information on menopausal status, type of menopause (natural, surgical, radiation/chemotherapy), hormone therapy use and weight was updated every two years along with information on smoking, physical activity and other behavioral and health-related factors. Multivariable logistic regression was used to estimate odds ratios for early menopause, defined as natural menopause before age 45 years, by aspects of adiposity.
Early natural menopause was reported by 2804 participants. Body mass index (BMI) was non-linearly associated with risk for early menopause. Compared to women with BMI = 18.5-22.4 kg/m2, those with BMI < 18.5 kg/m2 had a significant 30% higher odds of early menopause (95% confidence interval (CI) = 1.08, 1.57), while women with BMIs between 25.0-29.9 kg/m2 had significant 21-30% lower odds. Odds were not higher in women with BMI ≥ 35.0 kg/m2 in fully adjusted analysis. Non-linear associations with higher odds in underweight women were also observed for age 18 and age 35 BMI, though lower odds for overweight women was only observed for age 35 BMI. Odds were highest among women with age 18 BMI < 18.5 kg/m2 reporting severe weight cycling.
Though weight and early menopause status were self-reported, validation studies conducted among Nurses' Health Study participants suggest that self-reported weight is highly correlated with directly measured weight, and prospective self-reported menopausal status is highly reproducible. It is possible that underweight women may have been misclassified with an earlier age at menopause if being underweight led to amenorrhea.
In one of the few studies to prospectively examine a variety of adiposity measures and risk for early menopause, our findings that women who were underweight in early or mid-adulthood had elevated risk for early menopause can assist in efforts to better understand the etiology of early menopause. Additional prospective research is needed to understand how low adiposity may physiologically impact timing of menopause.
This study was conducted with funding from NIH UM1CA176726 and R01HD078517. The authors declare no conflicts of interest.
Not applicable.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/dex304</identifier><identifier>PMID: 29087465</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Abdominal Fat ; Adiposity ; Adult ; Body Mass Index ; Body Weight ; Female ; Follow-Up Studies ; Humans ; Menopause ; Menopause, Premature ; Middle Aged ; Multivariate Analysis ; Obesity - complications ; Odds Ratio ; Original ; Overweight - complications ; Premenopause ; Prospective Studies ; Risk Factors ; Surveys and Questionnaires ; Thinness - complications ; Thinness - epidemiology</subject><ispartof>Human reproduction (Oxford), 2017-12, Vol.32 (12), p.2522-2531</ispartof><rights>The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com</rights><rights>The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-836243835222320ed8abd017bd78a5c17535b33f2a50635e83e356c276bfeb023</citedby><cites>FETCH-LOGICAL-c387t-836243835222320ed8abd017bd78a5c17535b33f2a50635e83e356c276bfeb023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29087465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szegda, K L</creatorcontrib><creatorcontrib>Whitcomb, B W</creatorcontrib><creatorcontrib>Purdue-Smithe, A C</creatorcontrib><creatorcontrib>Boutot, M E</creatorcontrib><creatorcontrib>Manson, J E</creatorcontrib><creatorcontrib>Hankinson, S E</creatorcontrib><creatorcontrib>Rosner, B A</creatorcontrib><creatorcontrib>Bertone-Johnson, E R</creatorcontrib><title>Adult adiposity and risk of early menopause</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>Is adult adiposity associated with early menopause?
Overall and abdominal adiposity were non-linearly associated with odds for early natural menopause with elevated odds observed among women who were underweight in early or mid-adulthood compared to lean-normal weight women.
High and low adiposity have been associated with reproductive function and may potentially impact timing of menopause. It is unclear whether various aspects of adiposity are associated with risk of early menopause.
Prospective cohort study that examined data from 78 759 premenopausal women from the Nurses' Health Study II who were followed from 1989 to 2011 for incidence of early natural menopause.
Participants were aged 25-42 years and premenopausal at baseline in 1989, when information on menopausal status, height and weight was reported via questionnaire. Information on menopausal status, type of menopause (natural, surgical, radiation/chemotherapy), hormone therapy use and weight was updated every two years along with information on smoking, physical activity and other behavioral and health-related factors. Multivariable logistic regression was used to estimate odds ratios for early menopause, defined as natural menopause before age 45 years, by aspects of adiposity.
Early natural menopause was reported by 2804 participants. Body mass index (BMI) was non-linearly associated with risk for early menopause. Compared to women with BMI = 18.5-22.4 kg/m2, those with BMI < 18.5 kg/m2 had a significant 30% higher odds of early menopause (95% confidence interval (CI) = 1.08, 1.57), while women with BMIs between 25.0-29.9 kg/m2 had significant 21-30% lower odds. Odds were not higher in women with BMI ≥ 35.0 kg/m2 in fully adjusted analysis. Non-linear associations with higher odds in underweight women were also observed for age 18 and age 35 BMI, though lower odds for overweight women was only observed for age 35 BMI. Odds were highest among women with age 18 BMI < 18.5 kg/m2 reporting severe weight cycling.
Though weight and early menopause status were self-reported, validation studies conducted among Nurses' Health Study participants suggest that self-reported weight is highly correlated with directly measured weight, and prospective self-reported menopausal status is highly reproducible. It is possible that underweight women may have been misclassified with an earlier age at menopause if being underweight led to amenorrhea.
In one of the few studies to prospectively examine a variety of adiposity measures and risk for early menopause, our findings that women who were underweight in early or mid-adulthood had elevated risk for early menopause can assist in efforts to better understand the etiology of early menopause. Additional prospective research is needed to understand how low adiposity may physiologically impact timing of menopause.
This study was conducted with funding from NIH UM1CA176726 and R01HD078517. The authors declare no conflicts of interest.
Not applicable.</description><subject>Abdominal Fat</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Menopause</subject><subject>Menopause, Premature</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Obesity - complications</subject><subject>Odds Ratio</subject><subject>Original</subject><subject>Overweight - complications</subject><subject>Premenopause</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Thinness - complications</subject><subject>Thinness - epidemiology</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1LxDAQhoMo7rp69Co9ClI3yTRpehFk8QsWvOg5pM3UrbZNTVpx_71ddl30NC_MwzvDQ8g5o9eMZjBfDY3Hbm7xG2hyQKYskTTmIOghmVIuVcyYZBNyEsI7pWNU8phMeEZVmkgxJVe3dqj7yNiqc6Hq15FpbeSr8BG5MkLj63XUYOs6MwQ8JUelqQOe7eaMvN7fvSwe4-Xzw9PidhkXoNI-ViB5AgoE5xw4RatMbilLc5sqIwqWChA5QMmNoBIEKkAQsuCpzEvMKYcZudn2dkPeoC2w7b2pdeerxvi1dqbS_zdttdJv7ksLJWiSbQoudwXefQ4Yet1UocC6Ni26IWiWjSSkacJGNN6ihXcheCz3ZxjVG8F6K1hvBY_8xd_f9vSvUfgBdyd4Sw</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Szegda, K L</creator><creator>Whitcomb, B W</creator><creator>Purdue-Smithe, A C</creator><creator>Boutot, M E</creator><creator>Manson, J E</creator><creator>Hankinson, S E</creator><creator>Rosner, B A</creator><creator>Bertone-Johnson, E R</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171201</creationdate><title>Adult adiposity and risk of early menopause</title><author>Szegda, K L ; Whitcomb, B W ; Purdue-Smithe, A C ; Boutot, M E ; Manson, J E ; Hankinson, S E ; Rosner, B A ; Bertone-Johnson, E R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-836243835222320ed8abd017bd78a5c17535b33f2a50635e83e356c276bfeb023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Fat</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Menopause</topic><topic>Menopause, Premature</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Obesity - complications</topic><topic>Odds Ratio</topic><topic>Original</topic><topic>Overweight - complications</topic><topic>Premenopause</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Thinness - complications</topic><topic>Thinness - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szegda, K L</creatorcontrib><creatorcontrib>Whitcomb, B W</creatorcontrib><creatorcontrib>Purdue-Smithe, A C</creatorcontrib><creatorcontrib>Boutot, M E</creatorcontrib><creatorcontrib>Manson, J E</creatorcontrib><creatorcontrib>Hankinson, S E</creatorcontrib><creatorcontrib>Rosner, B A</creatorcontrib><creatorcontrib>Bertone-Johnson, E R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szegda, K L</au><au>Whitcomb, B W</au><au>Purdue-Smithe, A C</au><au>Boutot, M E</au><au>Manson, J E</au><au>Hankinson, S E</au><au>Rosner, B A</au><au>Bertone-Johnson, E R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult adiposity and risk of early menopause</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>32</volume><issue>12</issue><spage>2522</spage><epage>2531</epage><pages>2522-2531</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>Is adult adiposity associated with early menopause?
Overall and abdominal adiposity were non-linearly associated with odds for early natural menopause with elevated odds observed among women who were underweight in early or mid-adulthood compared to lean-normal weight women.
High and low adiposity have been associated with reproductive function and may potentially impact timing of menopause. It is unclear whether various aspects of adiposity are associated with risk of early menopause.
Prospective cohort study that examined data from 78 759 premenopausal women from the Nurses' Health Study II who were followed from 1989 to 2011 for incidence of early natural menopause.
Participants were aged 25-42 years and premenopausal at baseline in 1989, when information on menopausal status, height and weight was reported via questionnaire. Information on menopausal status, type of menopause (natural, surgical, radiation/chemotherapy), hormone therapy use and weight was updated every two years along with information on smoking, physical activity and other behavioral and health-related factors. Multivariable logistic regression was used to estimate odds ratios for early menopause, defined as natural menopause before age 45 years, by aspects of adiposity.
Early natural menopause was reported by 2804 participants. Body mass index (BMI) was non-linearly associated with risk for early menopause. Compared to women with BMI = 18.5-22.4 kg/m2, those with BMI < 18.5 kg/m2 had a significant 30% higher odds of early menopause (95% confidence interval (CI) = 1.08, 1.57), while women with BMIs between 25.0-29.9 kg/m2 had significant 21-30% lower odds. Odds were not higher in women with BMI ≥ 35.0 kg/m2 in fully adjusted analysis. Non-linear associations with higher odds in underweight women were also observed for age 18 and age 35 BMI, though lower odds for overweight women was only observed for age 35 BMI. Odds were highest among women with age 18 BMI < 18.5 kg/m2 reporting severe weight cycling.
Though weight and early menopause status were self-reported, validation studies conducted among Nurses' Health Study participants suggest that self-reported weight is highly correlated with directly measured weight, and prospective self-reported menopausal status is highly reproducible. It is possible that underweight women may have been misclassified with an earlier age at menopause if being underweight led to amenorrhea.
In one of the few studies to prospectively examine a variety of adiposity measures and risk for early menopause, our findings that women who were underweight in early or mid-adulthood had elevated risk for early menopause can assist in efforts to better understand the etiology of early menopause. Additional prospective research is needed to understand how low adiposity may physiologically impact timing of menopause.
This study was conducted with funding from NIH UM1CA176726 and R01HD078517. The authors declare no conflicts of interest.
Not applicable.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29087465</pmid><doi>10.1093/humrep/dex304</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction (Oxford), 2017-12, Vol.32 (12), p.2522-2531 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Abdominal Fat Adiposity Adult Body Mass Index Body Weight Female Follow-Up Studies Humans Menopause Menopause, Premature Middle Aged Multivariate Analysis Obesity - complications Odds Ratio Original Overweight - complications Premenopause Prospective Studies Risk Factors Surveys and Questionnaires Thinness - complications Thinness - epidemiology |
| title | Adult adiposity and risk of early menopause |
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