The Immunogenicity of Fractional Intradermal Doses of the Inactivated Poliovirus Vaccine Is Associated With the Size of the Intradermal Fluid Bleb

The immunogenicity of fractional (one-fifth, 0.1 mL) intradermal doses of the inactivated poliovirus vaccine (ID fIPV) is positively correlated with the size of the intradermal fluid bleb. Training of vaccinators for campaign and routine ID fIPV administration should focus on generating an 8- to 10-...

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Veröffentlicht in:	Clinical infectious diseases 2017-09, Vol.65 (5), p.851-854
Hauptverfasser:	Bibby, Jack, Saidu, Yauba, Umesi, Ama, Moneke-Anyanwoke, Ngozi, Bashorun, Adedapo O., Hydara, Mariama Badjie, Adigweme, Ikechukwu, Adetifa, Jane U., Okoye, Michael, Roberts, Elishia, Clemens, Ralf, Bandyopadhyay, Ananda S., Muhammad, Abdul K., Mulwa, Sarah, Royals, Michael, Jarrahian, Courtney, Jeffries, David, Kampmann, Beate, Clarke, Ed
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - blood Blister - epidemiology Blister - immunology BRIEF REPORTS Correlation analysis Drug dosages Gambia Humans Immunogenicity Infant Injections, Intradermal - statistics & numerical data Poliomyelitis Poliovirus Vaccine, Inactivated - administration & dosage Poliovirus Vaccine, Inactivated - immunology Poliovirus Vaccine, Inactivated - therapeutic use Seroepidemiologic Studies Vaccines Viruses
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Beschreibung
Zusammenfassung:	The immunogenicity of fractional (one-fifth, 0.1 mL) intradermal doses of the inactivated poliovirus vaccine (ID fIPV) is positively correlated with the size of the intradermal fluid bleb. Training of vaccinators for campaign and routine ID fIPV administration should focus on generating an 8- to 10-mm bleb with each injection. Clinical Trials Registration. NCT01847872
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/cix381