Clinical validation study of dried blood spot for determining everolimus concentration in patients with cancer

Purpose Everolimus treatment is seriously hampered by its toxicity profile. As a relationship between everolimus exposure and effectiveness and toxicity has been established, early and ongoing concentration measurement can be key to individualize the dose and optimize treatment outcomes. Dried blood...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of clinical pharmacology 2018-04, Vol.74 (4), p.465-471
Hauptverfasser:	Willemsen, A. E. C. A. B., Knapen, L. M., de Beer, Y. M., Brüggemann, R. J. M., Croes, S., van Herpen, C. M. L., van Erp, N. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adult Aged Antineoplastic Agents - administration & dosage Antineoplastic Agents - blood Antineoplastic Agents - pharmacokinetics Bias Biomedical and Life Sciences Biomedicine Blood Cancer Chromatography, Liquid Dried Blood Spot Testing Drug Dosage Calculations Drug Monitoring - methods Everolimus - administration & dosage Everolimus - blood Everolimus - pharmacokinetics Female Humans Inhibitor drugs Male Middle Aged Neoplasms - blood Neoplasms - drug therapy Pharmacokinetics and Disposition Pharmacology/Toxicology Predictive Value of Tests Regression analysis Reproducibility of Results Tandem Mass Spectrometry Targeted cancer therapy Toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!