Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement

Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement

No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He...

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Veröffentlicht in:Internal Medicine 2018/02/15, Vol.57(4), pp.563-568
Hauptverfasser: Tokunaga, Kenji, Yamamura, Ayako, Ueno, Shikiko, Kikukawa, Yoshitaka, Yamaguchi, Shunichiro, Hidaka, Michihiro, Matsuno, Naofumi, Kawaguchi, Tatsuya, Matsuoka, Masao, Okuno, Yutaka
Format: Artikel
Sprache:eng
Schlagworte:
Case Report
Computed tomography
Cytarabine
Emission analysis
Hematopoietic stem cells
Internal medicine
isolated myeloid sarcoma
pancreas
Pancreatic islet transplantation
Positron emission tomography
Remission
Runx1 protein
Sarcoma
Stem cell transplantation
t(8
21)
Tomography
Transplantation
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Zusammenfassung:No valid treatment for isolated myeloid sarcoma (IMS) has yet been established, and no thorough genetic examinations have been performed because of its low incidence and unique manner of development. We herein report a 34-year-old man with pancreatic IMS with t(8;21)/RUNX1-RUNX1T1 rearrangement. He was treated with high-dose cytarabine followed by allogeneic hematopoietic stem cell transplantation (allo-HSCT). This is the first report of pancreatic IMS with t(8;21). Positron emission tomography/computed tomography and genetic study are useful for the diagnosis, and allo-HSCT achieved complete remission in this patient.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.8912-17