Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma

ErbB3 has been widely implicated in treatment resistance, but its role as a primary treatment target is less clear. Canonically ErbB3 requires EGFR or ErbB2 for activation, whereas these two established treatment targets are thought to signal independently of ErbB3. In this study, we show that ErbB3...

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Veröffentlicht in:	Cell death & disease 2018-01, Vol.9 (1), p.5-5, Article 5
Hauptverfasser:	Redlich, Nathan, Robinson, Anthony M., Nickel, Kwangok P., Stein, Andrew P., Wheeler, Deric L., Adkins, Douglas R., Uppaluri, Ravindra, Kimple, Randall J., Van Tine, Brian A., Michel, Loren S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigens, Neoplasm - metabolism Biochemistry Biomedical and Life Sciences Cell Adhesion Molecules - metabolism Cell Biology Cell Culture Cell Line, Tumor Cetuximab - pharmacology Cetuximab - therapeutic use Cobalt - pharmacology Epidermal growth factor receptors ErbB protein ErbB-2 protein ErbB-3 protein Head & neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunology Life Sciences Mice Neuregulin Neuregulin 1 Neuregulin-1 - antagonists & inhibitors Neuregulin-1 - genetics Neuregulin-1 - metabolism Phosphatidylinositol 3-Kinases - metabolism Protein expression Proto-Oncogene Proteins c-akt - metabolism Receptor, ErbB-3 - antagonists & inhibitors Receptor, ErbB-3 - immunology Receptor, ErbB-3 - metabolism RNA Interference RNA, Small Interfering - metabolism Signal Transduction - drug effects Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - pathology Transplantation, Heterologous Treatment resistance Xenografts
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