GATA1 Is a Sensitive and Specific Nuclear Marker for Erythroid and Megakaryocytic Lineages

Abstract Objectives: GATA binding factor 1 (GATA1) is a transcription factor essential for erythromegakaryocytic differentiation. Given its function in lineage specification, we sought to evaluate the immunohistochemical profile of GATA1 in normal marrow and acute leukemia and assess the use of GATA...

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Veröffentlicht in:	American journal of clinical pathology 2017-04, Vol.147 (4), p.420-426
Hauptverfasser:	Lee, Winston Y., Weinberg, Olga K., Pinkus, Geraldine S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute myeloid leukemia Biopsy Bone marrow Bone Marrow - metabolism Bone Marrow - pathology Cell Differentiation Cell Nucleus - metabolism Erythroid Cells - metabolism Erythroid Cells - pathology Erythroleukemia GATA-1 protein GATA1 Transcription Factor - genetics GATA1 Transcription Factor - metabolism Genetic Markers - genetics Hematological diseases Humans Leukemia Leukemia, Erythroblastic, Acute - diagnosis Leukemia, Erythroblastic, Acute - metabolism Leukemia, Erythroblastic, Acute - pathology Leukemia, Megakaryoblastic, Acute - diagnosis Leukemia, Megakaryoblastic, Acute - metabolism Leukemia, Megakaryoblastic, Acute - pathology Leukocytes (eosinophilic) Lymphatic leukemia Lymphoma Mast cells Megakaryocytes Megakaryocytes - metabolism Megakaryocytes - pathology Metastases Myeloid leukemia Neoplasia Original Sensitivity and Specificity
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