Cancer Cell Discrimination Using Host–Guest “Doubled” Arrays

We report a nanosensor that uses cell lysates to rapidly profile the tumorigenicity of cancer cells. This sensing platform uses host–guest interactions between cucurbit[7]uril and the cationic headgroup of a gold nanoparticle to non-covalently modify the binding of three fluorescent proteins of a m...

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Veröffentlicht in:	Journal of the American Chemical Society 2017-06, Vol.139 (23), p.8008-8012
Hauptverfasser:	Le, Ngoc D. B, Yesilbag Tonga, Gulen, Mout, Rubul, Kim, Sung-Tae, Wille, Marcos E, Rana, Subinoy, Dunphy, Karen A, Jerry, D. Joseph, Yazdani, Mahdieh, Ramanathan, Rajesh, Rotello, Caren M, Rotello, Vincent M
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biosensing Techniques biosensors Bridged-Ring Compounds - chemistry Cell Line, Tumor cell lines fluorescent proteins Gold - chemistry Humans Imidazoles - chemistry Luminescent Proteins - chemistry Metal Nanoparticles - chemistry Molecular Structure nanogold Nanotechnology neoplasm cells neoplasms Neoplasms - diagnostic imaging Neoplasms - pathology
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