Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans
Summary A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early‐onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targe...
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| Veröffentlicht in: | Aging cell 2018-04, Vol.17 (2), p.n/a |
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| creator | Yousefzadeh, Matthew J. Schafer, Marissa J. Noren Hooten, Nicole Atkinson, Elizabeth J. Evans, Michele K. Baker, Darren J. Quarles, Ellen K. Robbins, Paul D. Ladiges, Warren C. LeBrasseur, Nathan K. Niedernhofer, Laura J. |
| description | Summary
A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early‐onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP‐1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein‐1 (MCP‐1) levels increased in an age‐dependent manner in wild‐type (WT) mice. That age‐dependent increase was accelerated in Ercc1−/Δ and Bubr1H/H mouse models of progeria. Genetic and pharmacologic interventions that slow aging of Ercc1−/Δ and WT mice lowered serum MCP‐1 levels significantly. Finally, in elderly humans with aortic stenosis, MCP‐1 levels were significantly higher in frail individuals compared to nonfrail. These data support the conclusion that MCP‐1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging. |
| doi_str_mv | 10.1111/acel.12706 |
| format | Article |
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A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early‐onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP‐1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein‐1 (MCP‐1) levels increased in an age‐dependent manner in wild‐type (WT) mice. That age‐dependent increase was accelerated in Ercc1−/Δ and Bubr1H/H mouse models of progeria. Genetic and pharmacologic interventions that slow aging of Ercc1−/Δ and WT mice lowered serum MCP‐1 levels significantly. Finally, in elderly humans with aortic stenosis, MCP‐1 levels were significantly higher in frail individuals compared to nonfrail. These data support the conclusion that MCP‐1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/acel.12706</identifier><identifier>PMID: 29290100</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Age ; Aged ; Aging ; Aging - genetics ; Animal models ; Animals ; Aortic stenosis ; biological age ; biomarkers of aging ; CCL2 ; chemokine ; Chemokine CCL2 - genetics ; Chemokine CCL2 - metabolism ; Chronic diseases ; Clinical trials ; ERCC1 protein ; Frailty - genetics ; Geriatrics ; geropathology ; Humans ; Mice ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Original ; Progeria ; Risk factors ; Stenosis</subject><ispartof>Aging cell, 2018-04, Vol.17 (2), p.n/a</ispartof><rights>2017 The Authors. published by the Anatomical Society and John Wiley & Sons Ltd.</rights><rights>2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 The Anatomical Society and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5156-2c3eec791560204bdaac2b643c966a2ab75a80dce3893508b49d164c4ed1076c3</citedby><cites>FETCH-LOGICAL-c5156-2c3eec791560204bdaac2b643c966a2ab75a80dce3893508b49d164c4ed1076c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847863/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847863/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29290100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yousefzadeh, Matthew J.</creatorcontrib><creatorcontrib>Schafer, Marissa J.</creatorcontrib><creatorcontrib>Noren Hooten, Nicole</creatorcontrib><creatorcontrib>Atkinson, Elizabeth J.</creatorcontrib><creatorcontrib>Evans, Michele K.</creatorcontrib><creatorcontrib>Baker, Darren J.</creatorcontrib><creatorcontrib>Quarles, Ellen K.</creatorcontrib><creatorcontrib>Robbins, Paul D.</creatorcontrib><creatorcontrib>Ladiges, Warren C.</creatorcontrib><creatorcontrib>LeBrasseur, Nathan K.</creatorcontrib><creatorcontrib>Niedernhofer, Laura J.</creatorcontrib><title>Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Summary
A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early‐onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP‐1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein‐1 (MCP‐1) levels increased in an age‐dependent manner in wild‐type (WT) mice. That age‐dependent increase was accelerated in Ercc1−/Δ and Bubr1H/H mouse models of progeria. Genetic and pharmacologic interventions that slow aging of Ercc1−/Δ and WT mice lowered serum MCP‐1 levels significantly. Finally, in elderly humans with aortic stenosis, MCP‐1 levels were significantly higher in frail individuals compared to nonfrail. These data support the conclusion that MCP‐1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging.</description><subject>Age</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - genetics</subject><subject>Animal models</subject><subject>Animals</subject><subject>Aortic stenosis</subject><subject>biological age</subject><subject>biomarkers of aging</subject><subject>CCL2</subject><subject>chemokine</subject><subject>Chemokine CCL2 - genetics</subject><subject>Chemokine CCL2 - metabolism</subject><subject>Chronic diseases</subject><subject>Clinical trials</subject><subject>ERCC1 protein</subject><subject>Frailty - genetics</subject><subject>Geriatrics</subject><subject>geropathology</subject><subject>Humans</subject><subject>Mice</subject><subject>Monocyte chemoattractant protein</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>Original</subject><subject>Progeria</subject><subject>Risk factors</subject><subject>Stenosis</subject><issn>1474-9718</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9ks-KFDEQxhtR3HX14gNIwIsIMybpdKdzEYZh_QMDXvQcqtPVM1nSyZh07zI3fQOf0Scx7ayjK2JySKXyqy_URxXFU0aXLK9XYNAtGZe0vlecMyHFQkle3z_FrDkrHqV0RSmTipYPizOuuKKM0vPi69pGMzkYrd8Sh9foEgk9GYIP5jAiMTscAoxjBDOCH8k-hhGt__7lGyOQCJB9vvvRgiMDQpoizuWtDS5srclZ2CKxngzWIAHfkT6CdeNhzu2mAXx6XDzowSV8cnteFJ_eXH5cv1tsPrx9v15tFqZiVb3gpkQ0UuWYciraDsDwthalUXUNHFpZQUM7g2Wjyoo2rVAdq4UR2DEqa1NeFK-PuvupHTCDPjfl9D7aAeJBB7D67ou3O70N17pqhGzqMgu8uBWI4fOEadSDTdl6Bx7DlDRTTcmrWlRNRp__hV6FKfrcnuaUlUxVvBG_qS041Nb3YbZ5FtUrSSup8q88U8t_UHl3mE0NHnub83cKXh4LTAwpRexPPTKq54HR88DonwOT4Wd_unJCf01IBtgRuMnfHP4jpVfry81R9Ac0P8yH</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Yousefzadeh, Matthew J.</creator><creator>Schafer, Marissa J.</creator><creator>Noren Hooten, Nicole</creator><creator>Atkinson, Elizabeth J.</creator><creator>Evans, Michele K.</creator><creator>Baker, Darren J.</creator><creator>Quarles, Ellen K.</creator><creator>Robbins, Paul D.</creator><creator>Ladiges, Warren C.</creator><creator>LeBrasseur, Nathan K.</creator><creator>Niedernhofer, Laura J.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201804</creationdate><title>Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans</title><author>Yousefzadeh, Matthew J. ; Schafer, Marissa J. ; Noren Hooten, Nicole ; Atkinson, Elizabeth J. ; Evans, Michele K. ; Baker, Darren J. ; Quarles, Ellen K. ; Robbins, Paul D. ; Ladiges, Warren C. ; LeBrasseur, Nathan K. ; Niedernhofer, Laura J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5156-2c3eec791560204bdaac2b643c966a2ab75a80dce3893508b49d164c4ed1076c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - genetics</topic><topic>Animal models</topic><topic>Animals</topic><topic>Aortic stenosis</topic><topic>biological age</topic><topic>biomarkers of aging</topic><topic>CCL2</topic><topic>chemokine</topic><topic>Chemokine CCL2 - genetics</topic><topic>Chemokine CCL2 - metabolism</topic><topic>Chronic diseases</topic><topic>Clinical trials</topic><topic>ERCC1 protein</topic><topic>Frailty - genetics</topic><topic>Geriatrics</topic><topic>geropathology</topic><topic>Humans</topic><topic>Mice</topic><topic>Monocyte chemoattractant protein</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Monocytes</topic><topic>Original</topic><topic>Progeria</topic><topic>Risk factors</topic><topic>Stenosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yousefzadeh, Matthew J.</creatorcontrib><creatorcontrib>Schafer, Marissa J.</creatorcontrib><creatorcontrib>Noren Hooten, Nicole</creatorcontrib><creatorcontrib>Atkinson, Elizabeth J.</creatorcontrib><creatorcontrib>Evans, Michele K.</creatorcontrib><creatorcontrib>Baker, Darren J.</creatorcontrib><creatorcontrib>Quarles, Ellen K.</creatorcontrib><creatorcontrib>Robbins, Paul D.</creatorcontrib><creatorcontrib>Ladiges, Warren C.</creatorcontrib><creatorcontrib>LeBrasseur, Nathan K.</creatorcontrib><creatorcontrib>Niedernhofer, Laura J.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yousefzadeh, Matthew J.</au><au>Schafer, Marissa J.</au><au>Noren Hooten, Nicole</au><au>Atkinson, Elizabeth J.</au><au>Evans, Michele K.</au><au>Baker, Darren J.</au><au>Quarles, Ellen K.</au><au>Robbins, Paul D.</au><au>Ladiges, Warren C.</au><au>LeBrasseur, Nathan K.</au><au>Niedernhofer, Laura J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2018-04</date><risdate>2018</risdate><volume>17</volume><issue>2</issue><epage>n/a</epage><issn>1474-9718</issn><eissn>1474-9726</eissn><abstract>Summary
A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early‐onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP‐1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein‐1 (MCP‐1) levels increased in an age‐dependent manner in wild‐type (WT) mice. That age‐dependent increase was accelerated in Ercc1−/Δ and Bubr1H/H mouse models of progeria. Genetic and pharmacologic interventions that slow aging of Ercc1−/Δ and WT mice lowered serum MCP‐1 levels significantly. Finally, in elderly humans with aortic stenosis, MCP‐1 levels were significantly higher in frail individuals compared to nonfrail. These data support the conclusion that MCP‐1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>29290100</pmid><doi>10.1111/acel.12706</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Aged Aging Aging - genetics Animal models Animals Aortic stenosis biological age biomarkers of aging CCL2 chemokine Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Chronic diseases Clinical trials ERCC1 protein Frailty - genetics Geriatrics geropathology Humans Mice Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Original Progeria Risk factors Stenosis |
| title | Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans |
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