The Relationship Between Oseltamivir and Suicide in Pediatric Patients
Abstract Purpose Studies examining the association between use of oseltamivir and neuropsychiatric events (including suicide) among children have had mixed findings and have been limited by small sample size, reliance on older data, and potential confounding. We undertook an analysis that addresses...
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| Veröffentlicht in: | Annals of family medicine 2018-03, Vol.16 (2), p.145-148 |
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| creator | Harrington, Rachel, BA Adimadhyam, Sruthi, MS Lee, Todd A., PharmD, PhD Schumock, Glen T., PharmD, MBA, PhD Antoon, James W., MD, PhD |
| description | Abstract Purpose Studies examining the association between use of oseltamivir and neuropsychiatric events (including suicide) among children have had mixed findings and have been limited by small sample size, reliance on older data, and potential confounding. We undertook an analysis that addresses these limitations. Methods Using a national administrative claims database and a case-crossover design that minimized confounding, we analyzed data from 5 contemporary influenza seasons (2009–2013) for individuals aged 1 to 18 years and ascertained oseltamivir exposure from pharmacy dispensing. Results We identified 21,407 suicide-related events during this study period, 251 of which were in oseltamivir-exposed children. In case-crossover analysis, we did not find any significant association with suicide either for oseltamivir exposure (odds ratio = 0.64; 95% CI, 0.39–1.00; P = .05) or for influenza diagnosis alone (odds ratio = 0.63; 95% CI, 0.34–1.08; P = .10). Conclusion Our findings suggest that oseltamivir does not increase risk of suicide in the pediatric population. |
| doi_str_mv | 10.1370/afm.2183 |
| format | Article |
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We undertook an analysis that addresses these limitations. Methods Using a national administrative claims database and a case-crossover design that minimized confounding, we analyzed data from 5 contemporary influenza seasons (2009–2013) for individuals aged 1 to 18 years and ascertained oseltamivir exposure from pharmacy dispensing. Results We identified 21,407 suicide-related events during this study period, 251 of which were in oseltamivir-exposed children. In case-crossover analysis, we did not find any significant association with suicide either for oseltamivir exposure (odds ratio = 0.64; 95% CI, 0.39–1.00; P = .05) or for influenza diagnosis alone (odds ratio = 0.63; 95% CI, 0.34–1.08; P = .10). Conclusion Our findings suggest that oseltamivir does not increase risk of suicide in the pediatric population.</description><identifier>ISSN: 1544-1709</identifier><identifier>EISSN: 1544-1717</identifier><identifier>DOI: 10.1370/afm.2183</identifier><identifier>PMID: 29531106</identifier><language>eng</language><publisher>United States: Annals of Family Medicine</publisher><subject>Adolescent ; Antiviral Agents - adverse effects ; Antiviral Agents - therapeutic use ; Child ; Child, Preschool ; Complications and side effects ; Cross-Over Studies ; Databases, Factual ; Drug therapy ; Family Medicine ; Female ; Humans ; Infant ; Influenza ; Influenza, Human - drug therapy ; Internal Medicine ; Logistic Models ; Male ; Odds Ratio ; Oseltamivir - adverse effects ; Oseltamivir - therapeutic use ; Oseltamivir phosphate ; Pediatric research ; Research Brief ; Risk factors ; Suicide ; Suicide - statistics & numerical data ; United States - epidemiology</subject><ispartof>Annals of family medicine, 2018-03, Vol.16 (2), p.145-148</ispartof><rights>Annals of Family Medicine, Inc.</rights><rights>2018 Annals of Family Medicine, Inc.</rights><rights>COPYRIGHT 2018 Annals of Family Medicine</rights><rights>2018 Annals of Family Medicine, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-bac3bfb2cadfb8603b119f4b18c02baa6773e8b2ee09610599f193b9cc51f7e93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847353/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847353/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29531106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harrington, Rachel, BA</creatorcontrib><creatorcontrib>Adimadhyam, Sruthi, MS</creatorcontrib><creatorcontrib>Lee, Todd A., PharmD, PhD</creatorcontrib><creatorcontrib>Schumock, Glen T., PharmD, MBA, PhD</creatorcontrib><creatorcontrib>Antoon, James W., MD, PhD</creatorcontrib><title>The Relationship Between Oseltamivir and Suicide in Pediatric Patients</title><title>Annals of family medicine</title><addtitle>Ann Fam Med</addtitle><description>Abstract Purpose Studies examining the association between use of oseltamivir and neuropsychiatric events (including suicide) among children have had mixed findings and have been limited by small sample size, reliance on older data, and potential confounding. We undertook an analysis that addresses these limitations. Methods Using a national administrative claims database and a case-crossover design that minimized confounding, we analyzed data from 5 contemporary influenza seasons (2009–2013) for individuals aged 1 to 18 years and ascertained oseltamivir exposure from pharmacy dispensing. Results We identified 21,407 suicide-related events during this study period, 251 of which were in oseltamivir-exposed children. In case-crossover analysis, we did not find any significant association with suicide either for oseltamivir exposure (odds ratio = 0.64; 95% CI, 0.39–1.00; P = .05) or for influenza diagnosis alone (odds ratio = 0.63; 95% CI, 0.34–1.08; P = .10). Conclusion Our findings suggest that oseltamivir does not increase risk of suicide in the pediatric population.</description><subject>Adolescent</subject><subject>Antiviral Agents - adverse effects</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Complications and side effects</subject><subject>Cross-Over Studies</subject><subject>Databases, Factual</subject><subject>Drug therapy</subject><subject>Family Medicine</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Influenza</subject><subject>Influenza, Human - drug therapy</subject><subject>Internal Medicine</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Odds Ratio</subject><subject>Oseltamivir - adverse effects</subject><subject>Oseltamivir - therapeutic use</subject><subject>Oseltamivir phosphate</subject><subject>Pediatric research</subject><subject>Research Brief</subject><subject>Risk factors</subject><subject>Suicide</subject><subject>Suicide - statistics & numerical data</subject><subject>United States - epidemiology</subject><issn>1544-1709</issn><issn>1544-1717</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVktFr1TAUxosobk7Bv0AKgvhyt5ykaZsXYQ7nhMGGm88hSU_XzDS5Ju2V_fem7u5ue8qB_M53ku87RfEeyCGwhhypfjyk0LIXxT7wqlpBA83LXU3EXvEmpVtCKFBGXxd7VHAGQOr94vR6wPInOjXZ4NNg1-VXnP4i-vIioZvUaDc2lsp35dVsje2wtL68xM6qKVpTXuY-9FN6W7zqlUv4bnseFL9Ov12fnK3OL77_ODk-XxnO6bTSyjDda2pU1-u2JkwDiL7S0BpCtVJ10zBsNUUkogbChehBMC2M4dA3KNhB8eVedz3rETuTZ0fl5DraUcU7GZSVz2-8HeRN2EjeVg3jLAt83grE8GfGNMnRJoPOKY9hTpISYBw4hzqjH-_RG-VQWt-HrGgWXB7XVBBeASWZ-vSEGlC5aUjBzf_9fA5uJ5sYUorY714NRC4pypyiXFLM6Ienv9yBD7E92oDZ643FKI2z3hrlfuMdptswR59jkCATlUReLYuw7EEWJ4Sxhv0DpeOrww</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Harrington, Rachel, BA</creator><creator>Adimadhyam, Sruthi, MS</creator><creator>Lee, Todd A., PharmD, PhD</creator><creator>Schumock, Glen T., PharmD, MBA, PhD</creator><creator>Antoon, James W., MD, PhD</creator><general>Annals of Family Medicine</general><general>American Academy of Family Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180301</creationdate><title>The Relationship Between Oseltamivir and Suicide in Pediatric Patients</title><author>Harrington, Rachel, BA ; Adimadhyam, Sruthi, MS ; Lee, Todd A., PharmD, PhD ; Schumock, Glen T., PharmD, MBA, PhD ; Antoon, James W., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-bac3bfb2cadfb8603b119f4b18c02baa6773e8b2ee09610599f193b9cc51f7e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Antiviral Agents - adverse effects</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Complications and side effects</topic><topic>Cross-Over Studies</topic><topic>Databases, Factual</topic><topic>Drug therapy</topic><topic>Family Medicine</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Influenza</topic><topic>Influenza, Human - drug therapy</topic><topic>Internal Medicine</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Odds Ratio</topic><topic>Oseltamivir - adverse effects</topic><topic>Oseltamivir - therapeutic use</topic><topic>Oseltamivir phosphate</topic><topic>Pediatric research</topic><topic>Research Brief</topic><topic>Risk factors</topic><topic>Suicide</topic><topic>Suicide - statistics & numerical data</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrington, Rachel, BA</creatorcontrib><creatorcontrib>Adimadhyam, Sruthi, MS</creatorcontrib><creatorcontrib>Lee, Todd A., PharmD, PhD</creatorcontrib><creatorcontrib>Schumock, Glen T., PharmD, MBA, PhD</creatorcontrib><creatorcontrib>Antoon, James W., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of family medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrington, Rachel, BA</au><au>Adimadhyam, Sruthi, MS</au><au>Lee, Todd A., PharmD, PhD</au><au>Schumock, Glen T., PharmD, MBA, PhD</au><au>Antoon, James W., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship Between Oseltamivir and Suicide in Pediatric Patients</atitle><jtitle>Annals of family medicine</jtitle><addtitle>Ann Fam Med</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>16</volume><issue>2</issue><spage>145</spage><epage>148</epage><pages>145-148</pages><issn>1544-1709</issn><eissn>1544-1717</eissn><abstract>Abstract Purpose Studies examining the association between use of oseltamivir and neuropsychiatric events (including suicide) among children have had mixed findings and have been limited by small sample size, reliance on older data, and potential confounding. We undertook an analysis that addresses these limitations. Methods Using a national administrative claims database and a case-crossover design that minimized confounding, we analyzed data from 5 contemporary influenza seasons (2009–2013) for individuals aged 1 to 18 years and ascertained oseltamivir exposure from pharmacy dispensing. Results We identified 21,407 suicide-related events during this study period, 251 of which were in oseltamivir-exposed children. In case-crossover analysis, we did not find any significant association with suicide either for oseltamivir exposure (odds ratio = 0.64; 95% CI, 0.39–1.00; P = .05) or for influenza diagnosis alone (odds ratio = 0.63; 95% CI, 0.34–1.08; P = .10). Conclusion Our findings suggest that oseltamivir does not increase risk of suicide in the pediatric population.</abstract><cop>United States</cop><pub>Annals of Family Medicine</pub><pmid>29531106</pmid><doi>10.1370/afm.2183</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Child Child, Preschool Complications and side effects Cross-Over Studies Databases, Factual Drug therapy Family Medicine Female Humans Infant Influenza Influenza, Human - drug therapy Internal Medicine Logistic Models Male Odds Ratio Oseltamivir - adverse effects Oseltamivir - therapeutic use Oseltamivir phosphate Pediatric research Research Brief Risk factors Suicide Suicide - statistics & numerical data United States - epidemiology |
| title | The Relationship Between Oseltamivir and Suicide in Pediatric Patients |
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