Spironolactone-induced unilateral gynecomastia
Gynecomastia is benign enlargement of male breast, drug-induced gynecomastia accounts for about 25%. We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness...
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| Veröffentlicht in: | International journal of applied and basic medical research 2018-01, Vol.8 (1), p.45-47 |
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| creator | Veeregowda, Sahana Krishnamurthy, Jayakumar Krishnaswamy, Bhuvana Narayana, Sarala |
| description | Gynecomastia is benign enlargement of male breast, drug-induced gynecomastia accounts for about 25%. We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Investigations revealed hypokalemia; he was advised to stop hydrochlorothiazide and consume potassium-rich diet; since he did not respond to this, spironolactone was added. The patient improved symptomatically but developed painful swelling of the right breast after 12 months of treatment which was suspected to be spironolactone-induced gynecomastia. Within a month of stopping the drug, pain in the right breast subsided followed by decrease in size of swelling. Literature search indicates bilateral gynecomastia by spironolactone, but when clinician encounters unilateral presentation, they should consider the possibility of drug-induced etiology. Patients should be educated about this while prescribing, and eplerenone can be a safe alternative. |
| doi_str_mv | 10.4103/ijabmr.IJABMR_399_16 |
| format | Article |
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We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Investigations revealed hypokalemia; he was advised to stop hydrochlorothiazide and consume potassium-rich diet; since he did not respond to this, spironolactone was added. The patient improved symptomatically but developed painful swelling of the right breast after 12 months of treatment which was suspected to be spironolactone-induced gynecomastia. Within a month of stopping the drug, pain in the right breast subsided followed by decrease in size of swelling. Literature search indicates bilateral gynecomastia by spironolactone, but when clinician encounters unilateral presentation, they should consider the possibility of drug-induced etiology. Patients should be educated about this while prescribing, and eplerenone can be a safe alternative.</description><identifier>ISSN: 2229-516X</identifier><identifier>EISSN: 2248-9606</identifier><identifier>DOI: 10.4103/ijabmr.IJABMR_399_16</identifier><identifier>PMID: 29552536</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Analysis ; Androgens ; Care and treatment ; Case Report ; Cell proliferation ; Complications and side effects ; Consent ; Dosage and administration ; Drug dosages ; Drug therapy ; Gynecomastia ; Higher education ; Hypertension ; Pain ; Patients ; Pharmacology ; Potassium ; Spironolactone ; Testosterone</subject><ispartof>International journal of applied and basic medical research, 2018-01, Vol.8 (1), p.45-47</ispartof><rights>COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt. Ltd. Jan/Mar 2018</rights><rights>Copyright: © 2018 International Journal of Applied and Basic Medical Research 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369l-1a01eaf676c2d337efa0b146acfb6d8261dd36e6fd739d6fe29f23724f0bb41e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846220/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846220/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4022,27457,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29552536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veeregowda, Sahana</creatorcontrib><creatorcontrib>Krishnamurthy, Jayakumar</creatorcontrib><creatorcontrib>Krishnaswamy, Bhuvana</creatorcontrib><creatorcontrib>Narayana, Sarala</creatorcontrib><title>Spironolactone-induced unilateral gynecomastia</title><title>International journal of applied and basic medical research</title><addtitle>Int J Appl Basic Med Res</addtitle><description>Gynecomastia is benign enlargement of male breast, drug-induced gynecomastia accounts for about 25%. We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Investigations revealed hypokalemia; he was advised to stop hydrochlorothiazide and consume potassium-rich diet; since he did not respond to this, spironolactone was added. The patient improved symptomatically but developed painful swelling of the right breast after 12 months of treatment which was suspected to be spironolactone-induced gynecomastia. Within a month of stopping the drug, pain in the right breast subsided followed by decrease in size of swelling. Literature search indicates bilateral gynecomastia by spironolactone, but when clinician encounters unilateral presentation, they should consider the possibility of drug-induced etiology. Patients should be educated about this while prescribing, and eplerenone can be a safe alternative.</description><subject>Analysis</subject><subject>Androgens</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Cell proliferation</subject><subject>Complications and side effects</subject><subject>Consent</subject><subject>Dosage and administration</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Gynecomastia</subject><subject>Higher education</subject><subject>Hypertension</subject><subject>Pain</subject><subject>Patients</subject><subject>Pharmacology</subject><subject>Potassium</subject><subject>Spironolactone</subject><subject>Testosterone</subject><issn>2229-516X</issn><issn>2248-9606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kV1rFDEUhgdRbKn9ByIFwbtZ83mycyOspa2VSsEP8C5k8rGbbSZZkxmX_ntTtq3dm-YmgTzn5T08TfMWoxnDiH70a9UPeXb5dfH523dJu05ieNEcEsLmbQcIXt69SddyDL8PmuNS1qgeIAKAvW4OSMc54RQOm9mPjc8ppqD0mKJtfTSTtuZkij6o0WYVTpa30eo0qDJ69aZ55VQo9vj-Pmp-nZ_9PP3SXl1fXJ4urlpNoQstVghb5UCAJoZSYZ1CPWagtOvBzAlgYyhYcEbQzoCzpHOECsIc6nuGLT1qPu1yN1M_WKNtHGsVucl-UPlWJuXl_k_0K7lMfyWfMyAE1YD39wE5_ZlsGeU6TTnWzpIgJDrB51T8p5YqWOmjSzVMD75oueBECMo4gUp9eEKtrArjqqQwjT7Fsg-yHahzKiVb91gYI3nnTe68yT1vdezd02Ufhx4sVeBsB2xTqE7KTZi2NsvK3sS0fTZcMi4fFNN_phuuUw</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Veeregowda, Sahana</creator><creator>Krishnamurthy, Jayakumar</creator><creator>Krishnaswamy, Bhuvana</creator><creator>Narayana, Sarala</creator><general>Wolters Kluwer India Pvt. 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We are reporting a case of spironolactone-induced unilateral gynecomastia. A 52-year-old male patient receiving multiple antihypertensives including hydrochlorothiazide presented with muscle weakness and easy fatigability. Investigations revealed hypokalemia; he was advised to stop hydrochlorothiazide and consume potassium-rich diet; since he did not respond to this, spironolactone was added. The patient improved symptomatically but developed painful swelling of the right breast after 12 months of treatment which was suspected to be spironolactone-induced gynecomastia. Within a month of stopping the drug, pain in the right breast subsided followed by decrease in size of swelling. Literature search indicates bilateral gynecomastia by spironolactone, but when clinician encounters unilateral presentation, they should consider the possibility of drug-induced etiology. 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| subjects | Analysis Androgens Care and treatment Case Report Cell proliferation Complications and side effects Consent Dosage and administration Drug dosages Drug therapy Gynecomastia Higher education Hypertension Pain Patients Pharmacology Potassium Spironolactone Testosterone |
| title | Spironolactone-induced unilateral gynecomastia |
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