Enterococcus faecalis and pathogenic streptococci inactivate daptomycin by releasing phospholipids

Daptomycin is a lipopeptide antibiotic with activity against Gram-positive bacteria. We showed previously that Staphylococcus aureus can survive daptomycin exposure by releasing membrane phospholipids that inactivate the antibiotic. To determine whether other pathogens possess this defence mechanism...

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Veröffentlicht in:	Microbiology (Society for General Microbiology) 2017-10, Vol.163 (10), p.1502-1508
Hauptverfasser:	Ledger, Elizabeth V K, Pader, Vera, Edwards, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Daptomycin - metabolism Daptomycin - pharmacology Enterococcus faecalis - drug effects Enterococcus faecalis - physiology Inactivation, Metabolic Lipid Metabolism Microbial Sensitivity Tests Phospholipids - biosynthesis Short Communication Staphylococcus aureus - drug effects Staphylococcus aureus - metabolism Streptococcus - drug effects Streptococcus - physiology Time Factors
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