Probiotics and necrotizing enterocolitis
In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). We review the role of the microbiome in NEC and pre-clinical data on mechanisms of probiotic action. Next, we summarize existing randomized controlled trials and observational stud...
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| Veröffentlicht in: | Seminars in pediatric surgery 2018-02, Vol.27 (1), p.39-46 |
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| container_title | Seminars in pediatric surgery |
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| creator | Patel, Ravi Mangal Underwood, Mark A. |
| description | In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). We review the role of the microbiome in NEC and pre-clinical data on mechanisms of probiotic action. Next, we summarize existing randomized controlled trials and observational studies of probiotics to prevent NEC. We also summarize findings from several recent meta-analyses and report a new cumulative meta-analysis of probiotic trials. Finally, we review data from cohorts routinely using commercially available probiotics. Our goal is to inform clinicians about the risks and benefits of probiotics, which may be helpful for those considering use in preterm infants to prevent NEC, death, or sepsis. |
| doi_str_mv | 10.1053/j.sempedsurg.2017.11.008 |
| format | Article |
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Our goal is to inform clinicians about the risks and benefits of probiotics, which may be helpful for those considering use in preterm infants to prevent NEC, death, or sepsis.</description><subject>Bacteria</subject><subject>Enterocolitis, Necrotizing - microbiology</subject><subject>Enterocolitis, Necrotizing - prevention & control</subject><subject>Gastrointestinal Microbiome</subject><subject>Gut</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - microbiology</subject><subject>Infant, Premature, Diseases - prevention & control</subject><subject>Meta-analysis</subject><subject>Microbiome</subject><subject>Neonate</subject><subject>Preterm</subject><subject>Probiotics - therapeutic use</subject><subject>Treatment Outcome</subject><issn>1055-8586</issn><issn>1532-9453</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwzAMhiMEYmPwF9COu6zESdOkFySY-JKQ4ADnqE3dkalrRtJOgl9Ppo0BJy5JHL9-bT-EjIEmQAW_WCQBlyusQu_nCaMgE4CEUnVAhiA4m-ap4IfxTYWYKqGyATkJYUEpyzImjsmA5UwKBdmQTJ69K63rrAnjoq3GLRofo0_bzsfYduidcY3tbDglR3XRBDzb3SPyenvzMrufPj7dPcyuHqdG8LSLJzBZcwamFKgEZTWWFa-xkKpmuZRFWgJk3KRgTM6MApWjSlktc6wMlxkfkcut76ovl_EvDuGLRq-8XRb-Q7vC6r-Z1r7puVtrodI0yzcGk52Bd-89hk4vbTDYNEWLrg8ackWBMqVklKqtNO4cgsd63wao3oDWC_0DWm9AawAdQcfS899j7gu_yUbB9VaAEdbaotfBWGwNVtaj6XTl7P9dvgDgCpXG</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Patel, Ravi Mangal</creator><creator>Underwood, Mark A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180201</creationdate><title>Probiotics and necrotizing enterocolitis</title><author>Patel, Ravi Mangal ; Underwood, Mark A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-c5127f321cb5e8502febd3fea78f2977a4b1163c41cc92c8189e842f79edc3763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bacteria</topic><topic>Enterocolitis, Necrotizing - microbiology</topic><topic>Enterocolitis, Necrotizing - prevention & control</topic><topic>Gastrointestinal Microbiome</topic><topic>Gut</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - microbiology</topic><topic>Infant, Premature, Diseases - prevention & control</topic><topic>Meta-analysis</topic><topic>Microbiome</topic><topic>Neonate</topic><topic>Preterm</topic><topic>Probiotics - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Ravi Mangal</creatorcontrib><creatorcontrib>Underwood, Mark A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Ravi Mangal</au><au>Underwood, Mark A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotics and necrotizing enterocolitis</atitle><jtitle>Seminars in pediatric surgery</jtitle><addtitle>Semin Pediatr Surg</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>27</volume><issue>1</issue><spage>39</spage><epage>46</epage><pages>39-46</pages><issn>1055-8586</issn><eissn>1532-9453</eissn><abstract>In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). 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| fulltext | fulltext |
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| ispartof | Seminars in pediatric surgery, 2018-02, Vol.27 (1), p.39-46 |
| issn | 1055-8586 1532-9453 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Bacteria Enterocolitis, Necrotizing - microbiology Enterocolitis, Necrotizing - prevention & control Gastrointestinal Microbiome Gut Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - microbiology Infant, Premature, Diseases - prevention & control Meta-analysis Microbiome Neonate Preterm Probiotics - therapeutic use Treatment Outcome |
| title | Probiotics and necrotizing enterocolitis |
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