The drug interaction potential of daprodustat when coadministered with pioglitazone, rosuvastatin, or trimethoprim in healthy subjects

This study was conducted to evaluate the likelihood of daprodustat to act as a perpetrator in drug–drug interactions (DDI) with the CYP2C8 enzyme and OATP1B1 transporter using the probe substrates pioglitazone and rosuvastatin as potential victims, respectively. Additionally, this study assessed the...

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Veröffentlicht in:	Pharmacology research & perspectives 2018-04, Vol.6 (2), p.e00327-n/a
Hauptverfasser:	Caltabiano, Stephen, Mahar, Kelly M., Lister, Karyn, Tenero, David, Ravindranath, Ramiya, Cizman, Borut, Cobitz, Alexander R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Anemia Antibiotics Barbiturates - administration & dosage Barbiturates - blood Barbiturates - pharmacology Body mass index Cell adhesion & migration Chronic kidney disease Clinical medicine Cross-Over Studies Cytochrome Cytochrome P-450 CYP2C8 - metabolism Drug dosages drug interaction Drug Interactions Enzymes Family medical history Female Females Glycine - administration & dosage Glycine - analogs & derivatives Glycine - blood Glycine - pharmacology Healthy Volunteers Hemodialysis Hemoglobin Humans Hypoxia Kidney diseases Male Metabolism Metabolites Motility Original Pharmacology phase I Rosuvastatin Calcium - administration & dosage Rosuvastatin Calcium - blood Solute Carrier Organic Anion Transporter Family Member 1b1 - metabolism Studies Substrate Specificity Thiazolidinediones - administration & dosage Thiazolidinediones - blood Trimethoprim - administration & dosage Trimethoprim - blood Trimethoprim - pharmacology
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