The Use of Magnetic Resonance Imaging for Non-Invasive Assessment of Venofer® Biodistribution in Rats

Purpose The aim of this study was to determine the potential of magnetic resonance imaging to evaluate the biodistribution of exogenous iron within 24 h after one single injection of Venofer® (iron sucrose). Methods Venofer® was evaluated in vitro for its ability to generate contrast in MR images. S...

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Veröffentlicht in:	Pharmaceutical research 2018-04, Vol.35 (4), p.88-12, Article 88
Hauptverfasser:	Span, Kimberley, Pieters, Ebel H. E., Hennink, Wim E., van der Toorn, Annette, Brinks, Vera, Dijkhuizen, Rick M., van Tilborg, Geralda A. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Body weight Bone marrow Drug Evaluation, Preclinical - methods Ferric Oxide, Saccharated - administration & dosage Ferric Oxide, Saccharated - pharmacokinetics Half-Life Hematinics - administration & dosage Hematinics - pharmacokinetics Image contrast Injection Injections, Intravenous Iron Kidney - diagnostic imaging Kidney - metabolism Kidneys Liver Liver - diagnostic imaging Liver - metabolism Magnetic Resonance Imaging Male Medical Law Models, Animal Muscles Neuroimaging NMR Nuclear magnetic resonance Organs Oxidative stress Pharmacology/Toxicology Pharmacy Rats Rats, Sprague-Dawley Renal cortex Research Paper Resonance Spleen Spleen - diagnostic imaging Spleen - metabolism Sucrose Sugar Tissue Distribution Whole Body Imaging
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