Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA

Abstract Introduction Monitoring the effectiveness of therapy early and accurately continues to be challenging. We hypothesize that determination of Human Epidermal Growth Factor Receptor 2 ( HER2 ) mRNA in malignant breast cancer (BC) cells by positron emission tomography (PET) imaging, before and...

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Veröffentlicht in:	Nuclear medicine and biology 2013-11, Vol.40 (8), p.994-999
Hauptverfasser:	Paudyal, Bishnuhari, Zhang, Kaijun, Chen, Chang-Po, Wampole, Matthew E, Mehta, Neil, Mitchell, Edith P, Gray, Brian D, Mattis, Jeffrey A, Pak, Koon Y, Thakur, Mathew L, Wickstrom, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Transformation, Neoplastic Copper Radioisotopes Copper-64 Doxorubicin Doxorubicin - therapeutic use Female HER2 Heterocyclic Compounds, 1-Ring - chemistry Humans Insulin-Like Growth Factor I - chemistry Mice Peptide nucleic acid Peptide Nucleic Acids - chemistry Peptide Nucleic Acids - metabolism Positron-Emission Tomography Radiology Receptor, ErbB-2 - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Tomography, X-Ray Computed Treatment Outcome
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