Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids

Summary Repository corticotrophin injection (RCI, H.P Acthar® gel) has been approved for use in the management of multiple autoimmune and inflammatory diseases for more than a half‐century, but its mechanism of action is not well understood. We used RNA‐Seq methods to define RCI‐regulated mRNAs in c...

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Veröffentlicht in:Clinical and experimental immunology 2018-04, Vol.192 (1), p.68-81
Hauptverfasser: Benko, A. L., McAloose, C. A., Becker, P. M., Wright, D., Sunyer, T., Kawasawa, Y. I., Olsen, N. J., Kovacs, W. J.
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Sprache:eng
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