Mycobacterium fortuitum-induced ER-Mitochondrial calcium dynamics promotes calpain/caspase-12/caspase-9 mediated apoptosis in fish macrophages

Mycobacterium fortuitum is a natural fish pathogen. It induces apoptosis in headkidney macrophages (HKM) of catfish, Clarias sp though the mechanism remains largely unknown. We observed M. fortuitum triggers calcium (Ca 2+ ) insult in the sub-cellular compartments which elicits pro-apototic ER-stres...

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Veröffentlicht in:	Cell death discovery 2018-02, Vol.4 (1), p.30-13, Article 30
Hauptverfasser:	Datta, Debika, Khatri, Preeti, Singh, Ambika, Saha, Dhira Rani, Verma, Gaurav, Raman, Rajagopal, Mazumder, Shibnath
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/326 Apoptosis Apposition Biochemistry Biomedical and Life Sciences Calcium (mitochondrial) Calcium mobilization Calcium permeability Calcium sequestration Calcium signalling Calpain Caspase Caspase-12 Caspase-9 Cell Biology Cell Cycle Analysis Cytochrome c Life Sciences Macrophages Membrane permeability Membrane potential Mitochondria Mitochondrial DNA Mycobacterium Pathogenesis Ruthenium red Stem Cells
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