Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

Nrf1-mediated proteosome activity in brown fat is required for the normal thermogenic behavior of this tissue in mice. Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or cold exposure, and they are thus an important cell type for the maintenance of proper metab...

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Veröffentlicht in:	Nature medicine 2018-03, Vol.24 (3), p.292-303
Hauptverfasser:	Bartelt, Alexander, Widenmaier, Scott B, Schlein, Christian, Johann, Kornelia, Goncalves, Renata L S, Eguchi, Kosei, Fischer, Alexander W, Parlakgül, Günes, Snyder, Nicole A, Nguyen, Truc B, Bruns, Oliver T, Franke, Daniel, Bawendi, Moungi G, Lynes, Matthew D, Leiria, Luiz O, Tseng, Yu-Hua, Inouye, Karen E, Arruda, Ana Paula, Hotamisligil, Gökhan S
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 38/1 38/39 42/41 42/44 59 631/443/319/1642/137/773 631/443/319/2723 631/443/319/333/1465 64/110 64/60 82/80 Acclimatization - genetics Acclimatization - physiology Adaptation Adaptive control Adipocytes Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Animal models Animals Biomedicine Cancer Research Care and treatment Cell metabolism Clonal deletion Cold Temperature Development and progression Endoplasmic reticulum Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - genetics Gene Deletion Genetic aspects Health aspects Homeostasis Humans Infectious Diseases Inflammation - genetics Inflammation - physiopathology Insulin Insulin Resistance - genetics Metabolic Diseases Metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Models, Animal Molecular Medicine Neurosciences NF-E2-Related Factor 1 - genetics Obesity Obesity - genetics Obesity - physiopathology Proteasome activator PA28a/b Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Proteasomes Quality control Rodents Thermogenesis Thermogenesis - genetics Transcription factors
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