Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

Alzheimer's disease (AD) is a neurodegenerative disease that causes late-onset dementia. The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide association studies. In mouse AD models, TREM2-deficient microglia fail to proliferate and cluster around the amyloid-β plaqu...

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Veröffentlicht in:	The Journal of experimental medicine 2018-03, Vol.215 (3), p.745-760
Hauptverfasser:	Song, Wilbur M, Joshita, Satoru, Zhou, Yingyue, Ulland, Tyler K, Gilfillan, Susan, Colonna, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation ADAM17 Protein - metabolism Alzheimer's disease Amyloid Animal models Animals Brain - pathology Cell Count Dementia disorders Gene polymorphism Genome-wide association studies Genomes Gliosis - genetics Gliosis - pathology Health risks Humans Lipids Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Transgenic Microglia Microglia - metabolism Myeloid Cells - metabolism Myeloid Cells - pathology Neurons Neurons - metabolism Polymorphism Polymorphism, Single Nucleotide - genetics Proteolysis Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Senile plaques Solubility Transgenic mice
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