Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression

fusions were recently reported as a new molecular feature of Invasive Mucinous Adenocarcinoma (IMA) of the lung. The chimeric ligand acts as a strong inductor of phosphorylation and tyrosine kinase activity of the ErbB2/ErbB3 heterodimer, thus enhancing the PI3K-AKT/MAPK pathways. The fusions were w...

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Veröffentlicht in:	Oncotarget 2018-02, Vol.9 (11), p.9661-9671
Hauptverfasser:	Trombetta, Domenico, Graziano, Paolo, Scarpa, Aldo, Sparaneo, Angelo, Rossi, Giulio, Rossi, Antonio, Di Maio, Massimo, Antonello, Davide, Mafficini, Andrea, Fabrizio, Federico Pio, Manzorra, Maria Carmina, Balsamo, Teresa, Centra, Flavia, Simbolo, Michele, Pantalone, Angela, Notarangelo, Michela, Parente, Paola, Lucia Dimitri, Maria Cecilia, Bonfitto, Antonio, Fiordelisi, Fabiola, Storlazzi, Clelia Tiziana, L'Abbate, Alberto, Taurchini, Marco, Maiello, Evaristo, Fazio, Vito Michele, Muscarella, Lucia Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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