Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial

IMPORTANCE: Dietary modification remains key to successful weight loss. Yet, no one dietary strategy is consistently superior to others for the general population. Previous research suggests genotype or insulin-glucose dynamics may modify the effects of diets. OBJECTIVE: To determine the effect of a...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2018-02, Vol.319 (7), p.667-679
Hauptverfasser:	Gardner, Christopher D, Trepanowski, John F, Del Gobbo, Liana C, Hauser, Michelle E, Rigdon, Joseph, Ioannidis, John P. A, Desai, Manisha, King, Abby C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Behavior modification Blood levels Body mass Body mass index Body size Body weight Body weight loss Carbohydrates Clinical trials Diabetes mellitus Diet Diet, Carbohydrate-Restricted Diet, Fat-Restricted Diet, Reducing Energy Intake Female Genotype Genotype & phenotype Genotypes Glucose Humans Impact analysis Insulin Insulin - blood Insulin Resistance Insulin secretion Intervention Low carbohydrate diet Low fat diet Male Middle Aged Nutrient deficiency Obesity - diet therapy Obesity - genetics Original Investigation Overweight Overweight - diet therapy Overweight - genetics Polymorphism Secretion Single-nucleotide polymorphism Weight control Weight Loss Young Adult
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