Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial
IMPORTANCE: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. OBJECTIVES: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson...
Gespeichert in:
| Veröffentlicht in: | JAMA neurology 2018-02, Vol.75 (2), p.219-226 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 226 |
|---|---|
| container_issue | 2 |
| container_start_page | 219 |
| container_title | JAMA neurology |
| container_volume | 75 |
| creator | Schenkman, Margaret Moore, Charity G Kohrt, Wendy M Hall, Deborah A Delitto, Anthony Comella, Cynthia L Josbeno, Deborah A Christiansen, Cory L Berman, Brian D Kluger, Benzi M Melanson, Edward L Jain, Samay Robichaud, Julie A Poon, Cynthia Corcos, Daniel M |
| description | IMPORTANCE: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. OBJECTIVES: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. DESIGN, SETTING, AND PARTICIPANTS: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors. Individuals from outpatient and community-based clinics were enrolled from May 1, 2012, through November 30, 2015, with the primary end point at 6 months. Individuals with idiopathic Parkinson disease (Hoehn and Yahr stages 1 or 2) aged 40 to 80 years within 5 years of diagnosis who were not exercising at moderate intensity greater than 3 times per week and not expected to need dopaminergic medication within 6 months participated in this study. A total of 384 volunteers were screened by telephone; 128 were randomly assigned to 1 of 3 groups (high-intensity exercise, moderate-intensity exercise, or control). INTERVENTIONS: High-intensity treadmill exercise (4 days per week, 80%-85% maximum heart rate [n = 43]), moderate-intensity treadmill exercise (4 days per week, 60%-65% maximum heart rate [n = 45]), or wait-list control (n = 40) for 6 months. MAIN OUTCOMES AND MEASURES: Feasibility measures were adherence to prescribed heart rate and exercise frequency of 3 days per week and safety. The clinical outcome was 6-month change in Unified Parkinson’s Disease Rating Scale motor score. RESULTS: A total of 128 patients were included in the study (mean [SD] age, 64 [9] years; age range, 40-80 years; 73 [57.0%] male; and 108 [84.4%] non-Hispanic white). Exercise rates were 2.8 (95% CI, 2.4-3.2) days per week at 80.2% (95% CI, 78.8%-81.7%) maximum heart rate in the high-intensity group and 3.2 (95% CI, 2.8-3.6; P = .13) days per week at 65.9% (95% CI, 64.2%-67.7%) maximum heart rate in the moderate-intensity group (P |
| doi_str_mv | 10.1001/jamaneurol.2017.3517 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5838616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>2664948</ama_id><sourcerecordid>1976003085</sourcerecordid><originalsourceid>FETCH-LOGICAL-a330t-bf4e42e2e6c91337e528eb0333add1da55384795ef94e84bcd401f0eab6e98293</originalsourceid><addsrcrecordid>eNpVkd1uEzEQhVcIRKvSF0AI-ZKbDf5br80FUpUGWqlABUVcWt7d2cbFawfbqUjfoe-Mo5QUfOPRzDlnRvqq6hXBM4IxeXtjJuNhHYObUUzaGWtI-6Q6pETIWpCmfbqvuTqojlO6weVJjDnjz6sDqiiVuFWH1f1iHKHPKIzozF4v63OfwSebN-gqghkm6xxa_IbY2wQoePQp5BDRt820ymFKyHp0abIFnxP6YfMSnQL6HG5D6caf1qfiOC1Ok-AdOkGXy1Igir4aP4TJ3sGA5s562xtX1lnjXlTPRuMSHD_8R9X3D4ur-Vl98eXj-fzkojaM4Vx3IwdOgYLoFWGshYZK6DBjzAwDGUzTMMlb1cCoOEje9QPHZMRgOgFKUsWOqve73NW6m2Doy_3ROL2KdjJxo4Ox-v-Jt0t9HW51I5kURJSANw8BMfxaQ8p6sqkH5wqVsE6aqFZgzLBsipTvpH0MKUUY92sI1luY-hGm3sLUW5jF9vrfE_emv-iK4OVOUNyPUyG44pL9ASPyqGA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1976003085</pqid></control><display><type>article</type><title>Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Schenkman, Margaret ; Moore, Charity G ; Kohrt, Wendy M ; Hall, Deborah A ; Delitto, Anthony ; Comella, Cynthia L ; Josbeno, Deborah A ; Christiansen, Cory L ; Berman, Brian D ; Kluger, Benzi M ; Melanson, Edward L ; Jain, Samay ; Robichaud, Julie A ; Poon, Cynthia ; Corcos, Daniel M</creator><creatorcontrib>Schenkman, Margaret ; Moore, Charity G ; Kohrt, Wendy M ; Hall, Deborah A ; Delitto, Anthony ; Comella, Cynthia L ; Josbeno, Deborah A ; Christiansen, Cory L ; Berman, Brian D ; Kluger, Benzi M ; Melanson, Edward L ; Jain, Samay ; Robichaud, Julie A ; Poon, Cynthia ; Corcos, Daniel M</creatorcontrib><description>IMPORTANCE: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. OBJECTIVES: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. DESIGN, SETTING, AND PARTICIPANTS: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors. Individuals from outpatient and community-based clinics were enrolled from May 1, 2012, through November 30, 2015, with the primary end point at 6 months. Individuals with idiopathic Parkinson disease (Hoehn and Yahr stages 1 or 2) aged 40 to 80 years within 5 years of diagnosis who were not exercising at moderate intensity greater than 3 times per week and not expected to need dopaminergic medication within 6 months participated in this study. A total of 384 volunteers were screened by telephone; 128 were randomly assigned to 1 of 3 groups (high-intensity exercise, moderate-intensity exercise, or control). INTERVENTIONS: High-intensity treadmill exercise (4 days per week, 80%-85% maximum heart rate [n = 43]), moderate-intensity treadmill exercise (4 days per week, 60%-65% maximum heart rate [n = 45]), or wait-list control (n = 40) for 6 months. MAIN OUTCOMES AND MEASURES: Feasibility measures were adherence to prescribed heart rate and exercise frequency of 3 days per week and safety. The clinical outcome was 6-month change in Unified Parkinson’s Disease Rating Scale motor score. RESULTS: A total of 128 patients were included in the study (mean [SD] age, 64 [9] years; age range, 40-80 years; 73 [57.0%] male; and 108 [84.4%] non-Hispanic white). Exercise rates were 2.8 (95% CI, 2.4-3.2) days per week at 80.2% (95% CI, 78.8%-81.7%) maximum heart rate in the high-intensity group and 3.2 (95% CI, 2.8-3.6; P = .13) days per week at 65.9% (95% CI, 64.2%-67.7%) maximum heart rate in the moderate-intensity group (P < .001). The mean change in Unified Parkinson’s Disease Rating Scale motor score in the high-intensity group was 0.3 (95% CI, −1.7 to 2.3) compared with 3.2 (95% CI, 1.4 to 5.1) in the usual care group (P = .03). The high-intensity group, but not the moderate-intensity group, reached the predefined nonfutility threshold compared with the control group. Anticipated adverse musculoskeletal events were not severe. CONCLUSIONS AND RELEVANCE: High-intensity treadmill exercise may be feasible and prescribed safely for patients with Parkinson disease. An efficacy trial is warranted to determine whether high-intensity treadmill exercise produces meaningful clinical benefits in de novo Parkinson disease. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01506479.</description><identifier>ISSN: 2168-6149</identifier><identifier>EISSN: 2168-6157</identifier><identifier>DOI: 10.1001/jamaneurol.2017.3517</identifier><identifier>PMID: 29228079</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Exercise Test - methods ; Exercise Therapy - methods ; Female ; High-Intensity Interval Training ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Online First ; Original Investigation ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Retrospective Studies ; Treatment Outcome</subject><ispartof>JAMA neurology, 2018-02, Vol.75 (2), p.219-226</ispartof><rights>Copyright 2017 American Medical Association. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamaneurology/articlepdf/10.1001/jamaneurol.2017.3517$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2017.3517$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,230,314,776,780,881,3327,27901,27902,76231,76234</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29228079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schenkman, Margaret</creatorcontrib><creatorcontrib>Moore, Charity G</creatorcontrib><creatorcontrib>Kohrt, Wendy M</creatorcontrib><creatorcontrib>Hall, Deborah A</creatorcontrib><creatorcontrib>Delitto, Anthony</creatorcontrib><creatorcontrib>Comella, Cynthia L</creatorcontrib><creatorcontrib>Josbeno, Deborah A</creatorcontrib><creatorcontrib>Christiansen, Cory L</creatorcontrib><creatorcontrib>Berman, Brian D</creatorcontrib><creatorcontrib>Kluger, Benzi M</creatorcontrib><creatorcontrib>Melanson, Edward L</creatorcontrib><creatorcontrib>Jain, Samay</creatorcontrib><creatorcontrib>Robichaud, Julie A</creatorcontrib><creatorcontrib>Poon, Cynthia</creatorcontrib><creatorcontrib>Corcos, Daniel M</creatorcontrib><title>Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial</title><title>JAMA neurology</title><addtitle>JAMA Neurol</addtitle><description>IMPORTANCE: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. OBJECTIVES: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. DESIGN, SETTING, AND PARTICIPANTS: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors. Individuals from outpatient and community-based clinics were enrolled from May 1, 2012, through November 30, 2015, with the primary end point at 6 months. Individuals with idiopathic Parkinson disease (Hoehn and Yahr stages 1 or 2) aged 40 to 80 years within 5 years of diagnosis who were not exercising at moderate intensity greater than 3 times per week and not expected to need dopaminergic medication within 6 months participated in this study. A total of 384 volunteers were screened by telephone; 128 were randomly assigned to 1 of 3 groups (high-intensity exercise, moderate-intensity exercise, or control). INTERVENTIONS: High-intensity treadmill exercise (4 days per week, 80%-85% maximum heart rate [n = 43]), moderate-intensity treadmill exercise (4 days per week, 60%-65% maximum heart rate [n = 45]), or wait-list control (n = 40) for 6 months. MAIN OUTCOMES AND MEASURES: Feasibility measures were adherence to prescribed heart rate and exercise frequency of 3 days per week and safety. The clinical outcome was 6-month change in Unified Parkinson’s Disease Rating Scale motor score. RESULTS: A total of 128 patients were included in the study (mean [SD] age, 64 [9] years; age range, 40-80 years; 73 [57.0%] male; and 108 [84.4%] non-Hispanic white). Exercise rates were 2.8 (95% CI, 2.4-3.2) days per week at 80.2% (95% CI, 78.8%-81.7%) maximum heart rate in the high-intensity group and 3.2 (95% CI, 2.8-3.6; P = .13) days per week at 65.9% (95% CI, 64.2%-67.7%) maximum heart rate in the moderate-intensity group (P < .001). The mean change in Unified Parkinson’s Disease Rating Scale motor score in the high-intensity group was 0.3 (95% CI, −1.7 to 2.3) compared with 3.2 (95% CI, 1.4 to 5.1) in the usual care group (P = .03). The high-intensity group, but not the moderate-intensity group, reached the predefined nonfutility threshold compared with the control group. Anticipated adverse musculoskeletal events were not severe. CONCLUSIONS AND RELEVANCE: High-intensity treadmill exercise may be feasible and prescribed safely for patients with Parkinson disease. An efficacy trial is warranted to determine whether high-intensity treadmill exercise produces meaningful clinical benefits in de novo Parkinson disease. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01506479.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Exercise Test - methods</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>High-Intensity Interval Training</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Online First</subject><subject>Original Investigation</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - therapy</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><issn>2168-6149</issn><issn>2168-6157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd1uEzEQhVcIRKvSF0AI-ZKbDf5br80FUpUGWqlABUVcWt7d2cbFawfbqUjfoe-Mo5QUfOPRzDlnRvqq6hXBM4IxeXtjJuNhHYObUUzaGWtI-6Q6pETIWpCmfbqvuTqojlO6weVJjDnjz6sDqiiVuFWH1f1iHKHPKIzozF4v63OfwSebN-gqghkm6xxa_IbY2wQoePQp5BDRt820ymFKyHp0abIFnxP6YfMSnQL6HG5D6caf1qfiOC1Ok-AdOkGXy1Igir4aP4TJ3sGA5s562xtX1lnjXlTPRuMSHD_8R9X3D4ur-Vl98eXj-fzkojaM4Vx3IwdOgYLoFWGshYZK6DBjzAwDGUzTMMlb1cCoOEje9QPHZMRgOgFKUsWOqve73NW6m2Doy_3ROL2KdjJxo4Ox-v-Jt0t9HW51I5kURJSANw8BMfxaQ8p6sqkH5wqVsE6aqFZgzLBsipTvpH0MKUUY92sI1luY-hGm3sLUW5jF9vrfE_emv-iK4OVOUNyPUyG44pL9ASPyqGA</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Schenkman, Margaret</creator><creator>Moore, Charity G</creator><creator>Kohrt, Wendy M</creator><creator>Hall, Deborah A</creator><creator>Delitto, Anthony</creator><creator>Comella, Cynthia L</creator><creator>Josbeno, Deborah A</creator><creator>Christiansen, Cory L</creator><creator>Berman, Brian D</creator><creator>Kluger, Benzi M</creator><creator>Melanson, Edward L</creator><creator>Jain, Samay</creator><creator>Robichaud, Julie A</creator><creator>Poon, Cynthia</creator><creator>Corcos, Daniel M</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180201</creationdate><title>Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial</title><author>Schenkman, Margaret ; Moore, Charity G ; Kohrt, Wendy M ; Hall, Deborah A ; Delitto, Anthony ; Comella, Cynthia L ; Josbeno, Deborah A ; Christiansen, Cory L ; Berman, Brian D ; Kluger, Benzi M ; Melanson, Edward L ; Jain, Samay ; Robichaud, Julie A ; Poon, Cynthia ; Corcos, Daniel M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-bf4e42e2e6c91337e528eb0333add1da55384795ef94e84bcd401f0eab6e98293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Exercise Test - methods</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>High-Intensity Interval Training</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Online First</topic><topic>Original Investigation</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - therapy</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schenkman, Margaret</creatorcontrib><creatorcontrib>Moore, Charity G</creatorcontrib><creatorcontrib>Kohrt, Wendy M</creatorcontrib><creatorcontrib>Hall, Deborah A</creatorcontrib><creatorcontrib>Delitto, Anthony</creatorcontrib><creatorcontrib>Comella, Cynthia L</creatorcontrib><creatorcontrib>Josbeno, Deborah A</creatorcontrib><creatorcontrib>Christiansen, Cory L</creatorcontrib><creatorcontrib>Berman, Brian D</creatorcontrib><creatorcontrib>Kluger, Benzi M</creatorcontrib><creatorcontrib>Melanson, Edward L</creatorcontrib><creatorcontrib>Jain, Samay</creatorcontrib><creatorcontrib>Robichaud, Julie A</creatorcontrib><creatorcontrib>Poon, Cynthia</creatorcontrib><creatorcontrib>Corcos, Daniel M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schenkman, Margaret</au><au>Moore, Charity G</au><au>Kohrt, Wendy M</au><au>Hall, Deborah A</au><au>Delitto, Anthony</au><au>Comella, Cynthia L</au><au>Josbeno, Deborah A</au><au>Christiansen, Cory L</au><au>Berman, Brian D</au><au>Kluger, Benzi M</au><au>Melanson, Edward L</au><au>Jain, Samay</au><au>Robichaud, Julie A</au><au>Poon, Cynthia</au><au>Corcos, Daniel M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial</atitle><jtitle>JAMA neurology</jtitle><addtitle>JAMA Neurol</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>75</volume><issue>2</issue><spage>219</spage><epage>226</epage><pages>219-226</pages><issn>2168-6149</issn><eissn>2168-6157</eissn><abstract>IMPORTANCE: Parkinson disease is a progressive neurologic disorder. Limited evidence suggests endurance exercise modifies disease severity, particularly high-intensity exercise. OBJECTIVES: To examine the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on motor symptoms warrants a phase 3 trial. DESIGN, SETTING, AND PARTICIPANTS: The Study in Parkinson Disease of Exercise (SPARX) was a phase 2, multicenter randomized clinical trial with 3 groups and masked assessors. Individuals from outpatient and community-based clinics were enrolled from May 1, 2012, through November 30, 2015, with the primary end point at 6 months. Individuals with idiopathic Parkinson disease (Hoehn and Yahr stages 1 or 2) aged 40 to 80 years within 5 years of diagnosis who were not exercising at moderate intensity greater than 3 times per week and not expected to need dopaminergic medication within 6 months participated in this study. A total of 384 volunteers were screened by telephone; 128 were randomly assigned to 1 of 3 groups (high-intensity exercise, moderate-intensity exercise, or control). INTERVENTIONS: High-intensity treadmill exercise (4 days per week, 80%-85% maximum heart rate [n = 43]), moderate-intensity treadmill exercise (4 days per week, 60%-65% maximum heart rate [n = 45]), or wait-list control (n = 40) for 6 months. MAIN OUTCOMES AND MEASURES: Feasibility measures were adherence to prescribed heart rate and exercise frequency of 3 days per week and safety. The clinical outcome was 6-month change in Unified Parkinson’s Disease Rating Scale motor score. RESULTS: A total of 128 patients were included in the study (mean [SD] age, 64 [9] years; age range, 40-80 years; 73 [57.0%] male; and 108 [84.4%] non-Hispanic white). Exercise rates were 2.8 (95% CI, 2.4-3.2) days per week at 80.2% (95% CI, 78.8%-81.7%) maximum heart rate in the high-intensity group and 3.2 (95% CI, 2.8-3.6; P = .13) days per week at 65.9% (95% CI, 64.2%-67.7%) maximum heart rate in the moderate-intensity group (P < .001). The mean change in Unified Parkinson’s Disease Rating Scale motor score in the high-intensity group was 0.3 (95% CI, −1.7 to 2.3) compared with 3.2 (95% CI, 1.4 to 5.1) in the usual care group (P = .03). The high-intensity group, but not the moderate-intensity group, reached the predefined nonfutility threshold compared with the control group. Anticipated adverse musculoskeletal events were not severe. CONCLUSIONS AND RELEVANCE: High-intensity treadmill exercise may be feasible and prescribed safely for patients with Parkinson disease. An efficacy trial is warranted to determine whether high-intensity treadmill exercise produces meaningful clinical benefits in de novo Parkinson disease. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01506479.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>29228079</pmid><doi>10.1001/jamaneurol.2017.3517</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-6149 |
| ispartof | JAMA neurology, 2018-02, Vol.75 (2), p.219-226 |
| issn | 2168-6149 2168-6157 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5838616 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adult Aged Aged, 80 and over Exercise Test - methods Exercise Therapy - methods Female High-Intensity Interval Training Humans Longitudinal Studies Male Middle Aged Online First Original Investigation Parkinson Disease - physiopathology Parkinson Disease - therapy Retrospective Studies Treatment Outcome |
| title | Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T03%3A34%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20High-Intensity%20Treadmill%20Exercise%20on%20Motor%20Symptoms%20in%20Patients%20With%20De%20Novo%20Parkinson%20Disease:%20A%20Phase%202%20Randomized%20Clinical%20Trial&rft.jtitle=JAMA%20neurology&rft.au=Schenkman,%20Margaret&rft.date=2018-02-01&rft.volume=75&rft.issue=2&rft.spage=219&rft.epage=226&rft.pages=219-226&rft.issn=2168-6149&rft.eissn=2168-6157&rft_id=info:doi/10.1001/jamaneurol.2017.3517&rft_dat=%3Cproquest_pubme%3E1976003085%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1976003085&rft_id=info:pmid/29228079&rft_ama_id=2664948&rfr_iscdi=true |