Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is characterized by fibrofatty infiltration of the myocardium and ventricular arrhythmias that may lead to sudden cardiac death. It has been observed that male patients develop the disease earlier and present with more severe phenoty...

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Veröffentlicht in:	European heart journal 2017-05, Vol.38 (19), p.1498-1508
Hauptverfasser:	Akdis, Deniz, Saguner, Ardan M, Shah, Khooshbu, Wei, Chuanyu, Medeiros-Domingo, Argelia, von Eckardstein, Arnold, Lüscher, Thomas F, Brunckhorst, Corinna, Chen, H S Vincent, Duru, Firat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Arrhythmogenic Right Ventricular Dysplasia - blood Arrhythmogenic Right Ventricular Dysplasia - etiology Biomarkers - metabolism Clinical Research Death, Sudden, Cardiac - etiology Desmosomes - genetics Estradiol - metabolism Exercise - physiology Female Gonadal Steroid Hormones - metabolism Humans Induced Pluripotent Stem Cells - physiology Male Middle Aged Models, Biological Myocytes, Cardiac - physiology Prognosis Sex Characteristics Testosterone - metabolism
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