Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel
OBJECTIVE:A pilot study was conducted to test the feasibility of using Department of Defense Serum Repository (DoDSR) samples to study health and exposure-related effects. METHODS:Thirty unidentified human serum samples were obtained from the DoDSR and analyzed for normal serum metabolites with high...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 2016-08, Vol.58 (8S), p.S44-S52 |
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| container_title | Journal of occupational and environmental medicine |
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| creator | Walker, Douglas I. Pennell, Kurt D. Uppal, Karan Xia, Xiaoyan Hopke, Philip K. Utell, Mark J. Phipps, Richard P. Sime, Patricia J. Rohrbeck, Patricia Mallon, Timothy M. Jones, Dean P. |
| description | OBJECTIVE:A pilot study was conducted to test the feasibility of using Department of Defense Serum Repository (DoDSR) samples to study health and exposure-related effects.
METHODS:Thirty unidentified human serum samples were obtained from the DoDSR and analyzed for normal serum metabolites with high-resolution mass spectrometry and serum levels of free benzo(a)pyrene (BaP) by gas chromatography-mass spectrometry. Metabolic associations with BaP were determined using a metabolome-wide association study (MWAS) and metabolic pathway enrichment.
RESULTS:The serum analysis detected normal ranges of glucose, selected amino acids, fatty acids, and creatinine. Free BaP was detected in a broad concentration range. MWAS of BaP showed associations with lipids, fatty acids, and sulfur amino acid metabolic pathways.
CONCLUSION:The results show that the DoDSR samples are of sufficient quality for chemical profiling of DoD personnel. |
| doi_str_mv | 10.1097/JOM.0000000000000772 |
| format | Article |
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METHODS:Thirty unidentified human serum samples were obtained from the DoDSR and analyzed for normal serum metabolites with high-resolution mass spectrometry and serum levels of free benzo(a)pyrene (BaP) by gas chromatography-mass spectrometry. Metabolic associations with BaP were determined using a metabolome-wide association study (MWAS) and metabolic pathway enrichment.
RESULTS:The serum analysis detected normal ranges of glucose, selected amino acids, fatty acids, and creatinine. Free BaP was detected in a broad concentration range. MWAS of BaP showed associations with lipids, fatty acids, and sulfur amino acid metabolic pathways.
CONCLUSION:The results show that the DoDSR samples are of sufficient quality for chemical profiling of DoD personnel.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/JOM.0000000000000772</identifier><identifier>PMID: 27501104</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</publisher><subject>Benzo(a)pyrene - analysis ; Blood Banks ; Environmental Exposure - adverse effects ; Humans ; Mass Spectrometry ; Metabolome ; Military Personnel ; Occupational Exposure - adverse effects ; Pilot Projects ; Serum - chemistry ; Supplement</subject><ispartof>Journal of occupational and environmental medicine, 2016-08, Vol.58 (8S), p.S44-S52</ispartof><rights>Copyright © 2016 American College of Occupational and Environmental Medicine</rights><rights>Copyright © 2016 by the American College of Occupational and Environmental Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4757-1574ac972efca5eedc0ed0e9fbf3164cef465cf1b68f6c86c0f48049a073f09e3</citedby><cites>FETCH-LOGICAL-c4757-1574ac972efca5eedc0ed0e9fbf3164cef465cf1b68f6c86c0f48049a073f09e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48501292$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48501292$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27501104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walker, Douglas I.</creatorcontrib><creatorcontrib>Pennell, Kurt D.</creatorcontrib><creatorcontrib>Uppal, Karan</creatorcontrib><creatorcontrib>Xia, Xiaoyan</creatorcontrib><creatorcontrib>Hopke, Philip K.</creatorcontrib><creatorcontrib>Utell, Mark J.</creatorcontrib><creatorcontrib>Phipps, Richard P.</creatorcontrib><creatorcontrib>Sime, Patricia J.</creatorcontrib><creatorcontrib>Rohrbeck, Patricia</creatorcontrib><creatorcontrib>Mallon, Timothy M.</creatorcontrib><creatorcontrib>Jones, Dean P.</creatorcontrib><title>Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel</title><title>Journal of occupational and environmental medicine</title><addtitle>J Occup Environ Med</addtitle><description>OBJECTIVE:A pilot study was conducted to test the feasibility of using Department of Defense Serum Repository (DoDSR) samples to study health and exposure-related effects.
METHODS:Thirty unidentified human serum samples were obtained from the DoDSR and analyzed for normal serum metabolites with high-resolution mass spectrometry and serum levels of free benzo(a)pyrene (BaP) by gas chromatography-mass spectrometry. Metabolic associations with BaP were determined using a metabolome-wide association study (MWAS) and metabolic pathway enrichment.
RESULTS:The serum analysis detected normal ranges of glucose, selected amino acids, fatty acids, and creatinine. Free BaP was detected in a broad concentration range. MWAS of BaP showed associations with lipids, fatty acids, and sulfur amino acid metabolic pathways.
CONCLUSION:The results show that the DoDSR samples are of sufficient quality for chemical profiling of DoD personnel.</description><subject>Benzo(a)pyrene - analysis</subject><subject>Blood Banks</subject><subject>Environmental Exposure - adverse effects</subject><subject>Humans</subject><subject>Mass Spectrometry</subject><subject>Metabolome</subject><subject>Military Personnel</subject><subject>Occupational Exposure - adverse effects</subject><subject>Pilot Projects</subject><subject>Serum - chemistry</subject><subject>Supplement</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9PFDEQxxujEUT_AzX7iA-L093-2H0xQSIq4QKJGhNfml5v6hW726PtSs6_3uLBCcxLJ535fmYyX0JeUjig0Mu3J2ezA7gbUjaPyC7lrah5z7rHJQcp6kbyZoc8S-kCgHIK_CnZKX9AKbBd8uPc-ZCrGWY9Dz4MWH93C6wOUwrG6ezCWH3J02JdBVu9x_FP2NdvVuuII1aulDBOQ3Ucw1DNnHdZx3V1jjGFcUT_nDyx2id8cfPukW_HH74efapPzz5-Pjo8rQ2TXNaUS6ZNLxu0RnPEhQFcAPZ2blsqmEHLBDeWzkVnhemEAcs6YL0G2Vrosd0j7zbc1TQfihzHHLVXq-iGso8K2qn7ldEt1c_wW_GulcBFAezfAGK4nDBlNbhk0Hs9YpiSol25Gucto6WVbVpNDClFtNsxFNS1LarYoh7aUmSv7664Fd368J97FXwuB_zlpyuMaona5-U1j7VSsLoBKqArPtb_yEX2aiO7SDnELZZ1Bdv0TfsXCkijRg</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Walker, Douglas I.</creator><creator>Pennell, Kurt D.</creator><creator>Uppal, Karan</creator><creator>Xia, Xiaoyan</creator><creator>Hopke, Philip K.</creator><creator>Utell, Mark J.</creator><creator>Phipps, Richard P.</creator><creator>Sime, Patricia J.</creator><creator>Rohrbeck, Patricia</creator><creator>Mallon, Timothy M.</creator><creator>Jones, Dean P.</creator><general>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</general><general>Copyright by the American College of Occupational and Environmental Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel</title><author>Walker, Douglas I. ; Pennell, Kurt D. ; Uppal, Karan ; Xia, Xiaoyan ; Hopke, Philip K. ; Utell, Mark J. ; Phipps, Richard P. ; Sime, Patricia J. ; Rohrbeck, Patricia ; Mallon, Timothy M. ; Jones, Dean P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4757-1574ac972efca5eedc0ed0e9fbf3164cef465cf1b68f6c86c0f48049a073f09e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Benzo(a)pyrene - analysis</topic><topic>Blood Banks</topic><topic>Environmental Exposure - adverse effects</topic><topic>Humans</topic><topic>Mass Spectrometry</topic><topic>Metabolome</topic><topic>Military Personnel</topic><topic>Occupational Exposure - adverse effects</topic><topic>Pilot Projects</topic><topic>Serum - chemistry</topic><topic>Supplement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walker, Douglas I.</creatorcontrib><creatorcontrib>Pennell, Kurt D.</creatorcontrib><creatorcontrib>Uppal, Karan</creatorcontrib><creatorcontrib>Xia, Xiaoyan</creatorcontrib><creatorcontrib>Hopke, Philip K.</creatorcontrib><creatorcontrib>Utell, Mark J.</creatorcontrib><creatorcontrib>Phipps, Richard P.</creatorcontrib><creatorcontrib>Sime, Patricia J.</creatorcontrib><creatorcontrib>Rohrbeck, Patricia</creatorcontrib><creatorcontrib>Mallon, Timothy M.</creatorcontrib><creatorcontrib>Jones, Dean P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walker, Douglas I.</au><au>Pennell, Kurt D.</au><au>Uppal, Karan</au><au>Xia, Xiaoyan</au><au>Hopke, Philip K.</au><au>Utell, Mark J.</au><au>Phipps, Richard P.</au><au>Sime, Patricia J.</au><au>Rohrbeck, Patricia</au><au>Mallon, Timothy M.</au><au>Jones, Dean P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>58</volume><issue>8S</issue><spage>S44</spage><epage>S52</epage><pages>S44-S52</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><abstract>OBJECTIVE:A pilot study was conducted to test the feasibility of using Department of Defense Serum Repository (DoDSR) samples to study health and exposure-related effects.
METHODS:Thirty unidentified human serum samples were obtained from the DoDSR and analyzed for normal serum metabolites with high-resolution mass spectrometry and serum levels of free benzo(a)pyrene (BaP) by gas chromatography-mass spectrometry. Metabolic associations with BaP were determined using a metabolome-wide association study (MWAS) and metabolic pathway enrichment.
RESULTS:The serum analysis detected normal ranges of glucose, selected amino acids, fatty acids, and creatinine. Free BaP was detected in a broad concentration range. MWAS of BaP showed associations with lipids, fatty acids, and sulfur amino acid metabolic pathways.
CONCLUSION:The results show that the DoDSR samples are of sufficient quality for chemical profiling of DoD personnel.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, a business of Wolters Kluwer Health</pub><pmid>27501104</pmid><doi>10.1097/JOM.0000000000000772</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Benzo(a)pyrene - analysis Blood Banks Environmental Exposure - adverse effects Humans Mass Spectrometry Metabolome Military Personnel Occupational Exposure - adverse effects Pilot Projects Serum - chemistry Supplement |
| title | Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel |
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