Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus

[Display omitted] •VacV skin infection generates highly functional effector and memory CD8+ T cells.•Both direct and cross-presentation of antigen activates naïve CD8+ T cells.•Effector and memory CD8+ T cells traffic into the skin during VacV infection.•CD8+ T cells migrate toward VacV-infected cel...

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Veröffentlicht in:	Current opinion in virology 2018-02, Vol.28, p.12-19
Hauptverfasser:	Hobbs, Samuel J, Osborn, Jossef F, Nolz, Jeffrey C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Administration, Cutaneous Animals CD8-Positive T-Lymphocytes - immunology Cell Differentiation Cell Movement - immunology Humans Immunologic Memory Lymphocyte Activation Mice Skin - immunology Skin - pathology Skin - virology Vaccinia virus - immunology
Online-Zugang:	Volltext
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