Phenytoin inhibits necroptosis

Receptor-interacting protein kinases 1 and 3 (RIPK1/3) have best been described for their role in mediating a regulated form of necrosis, referred to as necroptosis. During this process, RIPK3 phosphorylates mixed lineage kinase domain-like (MLKL) to cause plasma membrane rupture. RIPK3-deficient mi...

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Veröffentlicht in:	Cell death & disease 2018-03, Vol.9 (3), p.359-15, Article 359
Hauptverfasser:	von Mässenhausen, Anne, Tonnus, Wulf, Himmerkus, Nina, Parmentier, Simon, Saleh, Danish, Rodriguez, Diego, Ousingsawat, Jiraporn, Ang, Rosalind L., Weinberg, Joel M., Sanz, Ana B., Ortiz, Alberto, Zierleyn, Adrian, Becker, Jan Ulrich, Baratte, Blandine, Desban, Nathalie, Bach, Stéphane, Schiessl, Ina Maria, Nogusa, Shoko, Balachandran, Siddharth, Anders, Hans Joachim, Ting, Adrian T., Bleich, Markus, Degterev, Alexei, Kunzelmann, Karl, Bornstein, Stefan R., Green, Douglas R., Hugo, Christian, Linkermann, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - pathology Animal models Animals Antibodies Anticonvulsants - pharmacology Biochemistry Biomedical and Life Sciences Biopsy Blood flow Cell Biology Cell Culture Cell death Disease Models, Animal Gene Knockout Techniques HT29 Cells Humans Immunology Inflammation Ischemia Kidneys Kinases Life Sciences Male MAP kinase Medication Mice Mice, Inbred C57BL Mice, Knockout Necroptosis Necrosis - metabolism Necrosis - prevention & control Pharmaceutical sciences Pharmacology Phenytoin Phenytoin - pharmacology Protein Kinases - genetics Protein Kinases - metabolism Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors Receptor-Interacting Protein Serine-Threonine Kinases - genetics Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Reperfusion Reperfusion Injury - drug therapy Rodents Systemic Inflammatory Response Syndrome - chemically induced Systemic Inflammatory Response Syndrome - drug therapy Tubules Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α
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