CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair

Deletion of the chromatin remodeler chromodomain helicase DNA-binding protein 1 (CHD1) is a common genomic alteration found in human prostate cancers (PCas). CHD1 loss represents a distinct PCa subtype characterized by SPOP mutation and higher genomic instability. However, the role of CHD1 in PCa de...

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Veröffentlicht in:	Annals of oncology 2017-07, Vol.28 (7), p.1495-1507
Hauptverfasser:	Shenoy, T.R., Boysen, G., Wang, M.Y., Xu, Q.Z., Guo, W., Koh, F.M., Wang, C., Zhang, L.Z., Wang, Y., Gil, V., Aziz, S., Christova, R., Rodrigues, D.N., Crespo, M., Rescigno, P., Tunariu, N., Riisnaes, R., Zafeiriou, Z., Flohr, P., Yuan, W., Knight, E., Swain, A., Ramalho-Santos, M., Xu, D.Y., de Bono, J., Wu, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cdh1 Proteins - deficiency Cdh1 Proteins - genetics Cell Line, Tumor chromatin remodeler CHD1 Cross-Linking Reagents - pharmacology DDR DNA Breaks, Double-Stranded DNA End-Joining Repair Dose-Response Relationship, Drug Down-Regulation Gene Deletion Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease homologous recombination Humans Male Mice, Knockout non-homologous end joining Original PCa Phenotype Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Protein Stability Radiation Tolerance Recombinational DNA Repair synthetic lethality Time Factors Tumor Cells, Cultured Tumor Suppressor p53-Binding Protein 1 - metabolism
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