A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3

Increasing evidences reveal that autophagy inhibitor could enhance the effect of chemotherapy to cancer. However, few autophagy inhibitors are currently approved for clinical application in humans. Berbamine (BBM) is a natural compound extracted from traditional Chinese medicine that is widely used...

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Veröffentlicht in:	Cell death & disease 2018-02, Vol.9 (2), p.243-15, Article 243
Hauptverfasser:	Fu, Ruoqiu, Deng, Qin, Zhang, Hongwei, Hu, Xiaoye, Li, Yunong, Liu, Yanxia, Hu, Jinjiao, Luo, Qingsong, Zhang, Yanhao, Jiang, Xiuxing, Li, Lirong, Yang, Chong, Gao, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/89 14/19 A549 Cells Antibodies Antineoplastic Agents, Phytogenic - pharmacology Autophagosomes - metabolism Autophagosomes - virology Autophagy Autophagy - drug effects Autophagy - genetics Benzylisoquinolines - pharmacology Biochemistry Biomedical and Life Sciences BNIP3 protein Breast cancer Cancer Cell Biology Cell Culture Cell Line, Tumor Chemotherapy Gene Expression Regulation Humans Immunology Life Sciences Lysosomes - metabolism Lysosomes - virology MCF-7 Cells Membrane Fusion - drug effects Membrane Proteins - agonists Membrane Proteins - genetics Membrane Proteins - metabolism Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Phagocytosis Phagosomes Proto-Oncogene Proteins - agonists Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Qb-SNARE Proteins - genetics Qb-SNARE Proteins - metabolism Qc-SNARE Proteins - genetics Qc-SNARE Proteins - metabolism R-SNARE Proteins - genetics R-SNARE Proteins - metabolism Sequestosome-1 Protein - genetics Sequestosome-1 Protein - metabolism Signal Transduction SNAP receptors Traditional Chinese medicine Up-regulation
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