Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

Neuroblastoma (NB) is the most common malignant tumor in infancy and most common extracranial solid tumor in childhood. With the improvement of diagnosis and treatment, the survival rate of patients with low-risk and intermediate-risk NB can reach up to 90%. In contrast, for high-risk NBs, the long-...

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Veröffentlicht in:Cell death & disease 2018-01, Vol.9 (2), p.54-14, Article 54
Hauptverfasser: Tian, Xiangdong, Zhou, Dejun, Chen, Lu, Tian, Yao, Zhong, Benfu, Cao, Yanna, Dong, Qiuping, Zhou, Meng, Yan, Jie, Wang, Yalei, Qiu, Yanli, Zhang, Lianmin, Li, Zhongyuan, Wang, Huijuan, Wang, Daowei, Ying, Guoguang, Zhao, Qiang
Format: Artikel
Sprache:eng
Schlagworte:
1-Phosphatidylinositol 3-kinase
AKT protein
Animal research
Antibodies
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Children
Gene expression
Immunology
Kinases
Life Sciences
Mesenchyme
Metastases
Metastasis
Neuroblastoma
Polo-like kinase
Signal transduction
Solid tumors
Tumorigenesis
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Zusammenfassung:Neuroblastoma (NB) is the most common malignant tumor in infancy and most common extracranial solid tumor in childhood. With the improvement of diagnosis and treatment, the survival rate of patients with low-risk and intermediate-risk NB can reach up to 90%. In contrast, for high-risk NBs, the long-term survival rate is still
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-017-0088-2