Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway

Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but resistance limits its use. Due to the lack of proper models, mechanisms underlying PTX resistance in GC were not well studied. Using established PTX-resistant GC cell sublines HGC-27R, we for the first time i...

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Veröffentlicht in:	Cell death & disease 2018-01, Vol.9 (2), p.123-11, Article 123
Hauptverfasser:	Chen, Dongshao, Lin, Xiaoting, Zhang, Cheng, Liu, Zhentao, Chen, Zuhua, Li, Zhongwu, Wang, Jingyuan, Li, Beifang, Hu, Yanting, Dong, Bin, Shen, Lin, Ji, Jiafu, Gao, Jing, Zhang, Xiaotian
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animal models Animals Antibodies Antimitotic Agents - pharmacology Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line, Tumor Cell Shape - drug effects Chemotherapy Drug resistance Drug Resistance, Neoplasm - drug effects Epithelial-Mesenchymal Transition - drug effects Female Gastric cancer Humans Imidazoles - pharmacology Imidazoles - therapeutic use Immunology Kinases Life Sciences MAP kinase MEK inhibitors Mice, Inbred BALB C Mice, Nude Microtubules - drug effects Microtubules - metabolism Molecular modelling Paclitaxel Paclitaxel - pharmacology Paclitaxel - therapeutic use Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein expression Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-serine/threonine kinase Proto-Oncogene Proteins c-akt - metabolism Quinolines - pharmacology Quinolines - therapeutic use Rapamycin Signal Transduction - drug effects Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tubulin Tumors Vimentin
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