Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways

Glioblastoma multiforme (GBM) is one of the most devastating brain tumors with median survival of one year and presents unique challenges to therapy because of its aggressive behavior. Current treatment strategy involves surgery, radiotherapy, immunotherapy, and adjuvant chemotherapy even though opt...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-15
Hauptverfasser:	Akbor, Maruf Mohammad, Mostofa, A. G. M., Hossain, Md Kamal, Chowdhury, Fabliha Ahmed, Bin Sayeed, Muhammad Shahdaat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant treatment Angiogenesis Animals Anticancer properties Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - therapeutic use Apoptosis Benzoquinones - chemistry Benzoquinones - pharmacokinetics Benzoquinones - therapeutic use Biocompatibility Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cancer Cancer therapies Carcinogenesis Carcinogens Cell cycle Chemotherapy Clinical trials Complications Deoxyribonucleic acid DNA DNA methylation Drug delivery systems FDA approval Fibroblasts Glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Growth factors Health aspects Humans Immunotherapy Kinases Medical treatment Metabolism Mutation Nigella sativa Nigella sativa - chemistry Otolaryngology Proteins Radiation therapy Radiotherapy Review Rodents Signal transduction Signaling Surgery Toxicity Tumor cells Tumors
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