Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial

IMPORTANCE: Postoperative delirium occurs in 10% to 60% of elderly patients having major surgery and is associated with longer hospital stays, increased hospital costs, and 1-year mortality. Emerging literature suggests that dexmedetomidine sedation in critical care units is associated with reduced...

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Veröffentlicht in:	JAMA surgery 2017-08, Vol.152 (8), p.e171505-e171505
Hauptverfasser:	Deiner, Stacie, Luo, Xiaodong, Lin, Hung-Mo, Sessler, Daniel I, Saager, Leif, Sieber, Frederick E, Lee, Hochang B, Sano, Mary, Jankowski, Christopher, Bergese, Sergio D, Candiotti, Keith, Flaherty, Joseph H, Arora, Harendra, Shander, Aryeh, Rock, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists - administration & dosage Aged Cognitive Dysfunction - prevention & control Delirium - prevention & control Dexmedetomidine - administration & dosage Double-Blind Method Elective Surgical Procedures - methods Female Humans Infusions, Intravenous Intraoperative Care - methods Male Online First Online Only Original Investigation Postoperative Complications - prevention & control Treatment Failure
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