Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67)
Abstract Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients...
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| Veröffentlicht in: | Journal of neuroimmunology 2016-11, Vol.300, p.15-17 |
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| container_title | Journal of neuroimmunology |
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| creator | Verdaguer, Mar Guasp Solà-Valls, Nuria Martínez-Hernández, Eugenia Villar, M Pilar Gil Mingot, Cristina González Ruiz, Luis Brieva Saiz, Albert Dalmau, Josep Graus, Francesc Ariño, Helena |
| description | Abstract Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neurological disorders. We describe the case of a 59-year-old woman who presented with pancerebellar syndrome of subacute onset (9 weeks to nadir). In the etiological study, high titers of GAD-ab were found, but these only recognized the GAD67 isoform and not the GAD65. Screening of GAD67-ab should be considered in late-onset cerebellar ataxia when GAD65-ab are absent. |
| doi_str_mv | 10.1016/j.jneuroim.2016.09.019 |
| format | Article |
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Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neurological disorders. We describe the case of a 59-year-old woman who presented with pancerebellar syndrome of subacute onset (9 weeks to nadir). In the etiological study, high titers of GAD-ab were found, but these only recognized the GAD67 isoform and not the GAD65. Screening of GAD67-ab should be considered in late-onset cerebellar ataxia when GAD65-ab are absent.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2016.09.019</identifier><identifier>PMID: 27806870</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Autoantibodies - blood ; Biomarkers - blood ; Cerebellar Ataxia - blood ; Cerebellar Ataxia - diagnostic imaging ; Female ; Glutamate Decarboxylase - blood ; Humans ; Middle Aged ; Neurology</subject><ispartof>Journal of neuroimmunology, 2016-11, Vol.300, p.15-17</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c625t-1dbfb8bef2c53075ee1061f2434cb1ccfbb0d34b69331ee1691de9358a4f627d3</citedby><cites>FETCH-LOGICAL-c625t-1dbfb8bef2c53075ee1061f2434cb1ccfbb0d34b69331ee1691de9358a4f627d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2016.09.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27806870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verdaguer, Mar Guasp</creatorcontrib><creatorcontrib>Solà-Valls, Nuria</creatorcontrib><creatorcontrib>Martínez-Hernández, Eugenia</creatorcontrib><creatorcontrib>Villar, M Pilar Gil</creatorcontrib><creatorcontrib>Mingot, Cristina González</creatorcontrib><creatorcontrib>Ruiz, Luis Brieva</creatorcontrib><creatorcontrib>Saiz, Albert</creatorcontrib><creatorcontrib>Dalmau, Josep</creatorcontrib><creatorcontrib>Graus, Francesc</creatorcontrib><creatorcontrib>Ariño, Helena</creatorcontrib><title>Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67)</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neurological disorders. We describe the case of a 59-year-old woman who presented with pancerebellar syndrome of subacute onset (9 weeks to nadir). In the etiological study, high titers of GAD-ab were found, but these only recognized the GAD67 isoform and not the GAD65. Screening of GAD67-ab should be considered in late-onset cerebellar ataxia when GAD65-ab are absent.</description><subject>Allergy and Immunology</subject><subject>Autoantibodies - blood</subject><subject>Biomarkers - blood</subject><subject>Cerebellar Ataxia - blood</subject><subject>Cerebellar Ataxia - diagnostic imaging</subject><subject>Female</subject><subject>Glutamate Decarboxylase - blood</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neurology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktv1TAQhS0EopcLf6HKsiyS-hE7yaaiuoUWqRILYMHK8mNSHJK42E7V--9xdNsK2MDKsuacY898g9AxwRXBRJwO1TDDErybKprvFe4qTLpnaEPahpZtTclztMkFXvKGtkfoVYwDxoSzunuJjmjTYtE2eIO-7SCAhnFUoVBJ3TtVqNkWaklezclpbx3EIkBMwZkEtki-uBmXpCZnCmWcLSwYFbS_348qQiGa4uTy_EI0b1-jF70aI7x5OLfo64f3X3ZX5fWny4-78-vSCMpTSazudauhp4Yz3HAAggXpac1qo4kxvdbYslqLjjGSi6IjFjrGW1X3gjaWbdHZIfd20RNYA3MKapS3wU0q7KVXTv5Zmd13eePvJG8ZYV2bA04eAoL_ueRO5eSiWUcyg1-iJG0tWMcZp_8hZaJhgmbDFomD1AQfY4D-6UcEyxWhHOQjQrkilLiTGWE2Hv_ez5PtkVkWvDsIIE_1zkGQ0TiYDVgXwCRpvfv3G2d_RZjRzc6o8QfsIQ5-CXNmJomMVGL5eV2kdY-IYJiSHPALsL7Gjg</recordid><startdate>20161115</startdate><enddate>20161115</enddate><creator>Verdaguer, Mar Guasp</creator><creator>Solà-Valls, Nuria</creator><creator>Martínez-Hernández, Eugenia</creator><creator>Villar, M Pilar Gil</creator><creator>Mingot, Cristina González</creator><creator>Ruiz, Luis Brieva</creator><creator>Saiz, Albert</creator><creator>Dalmau, Josep</creator><creator>Graus, Francesc</creator><creator>Ariño, Helena</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20161115</creationdate><title>Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67)</title><author>Verdaguer, Mar Guasp ; Solà-Valls, Nuria ; Martínez-Hernández, Eugenia ; Villar, M Pilar Gil ; Mingot, Cristina González ; Ruiz, Luis Brieva ; Saiz, Albert ; Dalmau, Josep ; Graus, Francesc ; Ariño, Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-1dbfb8bef2c53075ee1061f2434cb1ccfbb0d34b69331ee1691de9358a4f627d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Allergy and Immunology</topic><topic>Autoantibodies - blood</topic><topic>Biomarkers - blood</topic><topic>Cerebellar Ataxia - blood</topic><topic>Cerebellar Ataxia - diagnostic imaging</topic><topic>Female</topic><topic>Glutamate Decarboxylase - blood</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neurology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verdaguer, Mar Guasp</creatorcontrib><creatorcontrib>Solà-Valls, Nuria</creatorcontrib><creatorcontrib>Martínez-Hernández, Eugenia</creatorcontrib><creatorcontrib>Villar, M Pilar Gil</creatorcontrib><creatorcontrib>Mingot, Cristina González</creatorcontrib><creatorcontrib>Ruiz, Luis Brieva</creatorcontrib><creatorcontrib>Saiz, Albert</creatorcontrib><creatorcontrib>Dalmau, Josep</creatorcontrib><creatorcontrib>Graus, Francesc</creatorcontrib><creatorcontrib>Ariño, Helena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verdaguer, Mar Guasp</au><au>Solà-Valls, Nuria</au><au>Martínez-Hernández, Eugenia</au><au>Villar, M Pilar Gil</au><au>Mingot, Cristina González</au><au>Ruiz, Luis Brieva</au><au>Saiz, Albert</au><au>Dalmau, Josep</au><au>Graus, Francesc</au><au>Ariño, Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67)</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2016-11-15</date><risdate>2016</risdate><volume>300</volume><spage>15</spage><epage>17</epage><pages>15-17</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). 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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Allergy and Immunology Autoantibodies - blood Biomarkers - blood Cerebellar Ataxia - blood Cerebellar Ataxia - diagnostic imaging Female Glutamate Decarboxylase - blood Humans Middle Aged Neurology |
| title | Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67) |
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