How Carrier Size and Valency Modulate Receptor-Mediated Signaling: Understanding the Link between Binding and Endocytosis of ICAM-1-Targeted Carriers

Targeting of drug carriers to endocytic cell receptors facilitates intracellular drug delivery. Carrier size and number of targeting moieties (valency) influence cell binding and uptake. However, how these parameters influence receptor-mediated cell signaling (the link between binding and uptake) re...

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Veröffentlicht in:	Biomacromolecules 2016-10, Vol.17 (10), p.3127-3137
Hauptverfasser:	Serrano, Daniel, Manthe, Rachel L, Paul, Eden, Chadha, Rishi, Muro, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Ceramides - biosynthesis Drug Carriers - chemistry Drug Carriers - therapeutic use Drug Delivery Systems Endocytosis - drug effects Gene Expression Regulation - drug effects Humans Intercellular Adhesion Molecule-1 - chemistry Intercellular Adhesion Molecule-1 - therapeutic use Polymers - chemistry Polymers - therapeutic use Protein Binding Protein Kinase C - biosynthesis
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