CD1d‐mediated lipid presentation by CD11c+ cells regulates intestinal homeostasis

Intestinal homeostasis relies on a continuous dialogue between the commensal bacteria and the immune system. Natural killer T (NKT) cells, which recognize CD1d‐restricted microbial lipids and self‐lipids, contribute to the regulation of mucosal immunity, yet the mechanisms underlying their functions...

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Veröffentlicht in:	The EMBO journal 2018-03, Vol.37 (5), p.n/a
Hauptverfasser:	Sáez de Guinoa, Julia, Jimeno, Rebeca, Gaya, Mauro, Kipling, David, Garzón, María José, Dunn‐Walters, Deborah, Ubeda, Carles, Barral, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD1d - biosynthesis Antigens, CD1d - genetics Antigens, CD1d - immunology Bacteria CD11c antigen CD11c Antigen - metabolism CD1d CD1d antigen Cell activation Clonal deletion Control Crosstalk Dendritic cells Dendritic Cells - immunology Digestive system Dysbacteriosis Dysbiosis - genetics EMBO19 Gastrointestinal Microbiome - immunology Gastrointestinal tract Homeostasis Immune system Immunity Immunoglobulin A Immunoglobulin A - immunology Immunoregulation Interleukin-4 - immunology Intestinal microflora Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestine Lipids Lymphocytes Lymphocytes T Macrophages Macrophages - immunology Membrane Lipids - immunology Mice Mice, Inbred C57BL Mice, Knockout Microbiota Microorganisms Mucosal immunity Natural killer cells Natural Killer T-Cells - immunology NKT cell Populations Regulation T cell receptors T-Lymphocytes, Regulatory - immunology
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